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- 2026年10月17日
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| 产品编号 | bs-5973R-APC |
| 英文名称 | SIRT7 Rabbit pAb, APC conjugated |
| 中文名称 | APC标记的沉默调节样蛋白SirT7抗体 |
| 英文别名 | NAD dependent deacetylase sirtuin 7; NAD-dependent deacetylase sirtuin-7; Silent mating type information regulation 2 homolog; Silent mating type information regulation 2 S.cerevisiae homolog 7; SIR2 L7; SIR2 like protein 7; Sir2 related protein type 7; SIR2, S.CEREVISIAE, HOMOLOG-LIKE 7; SIR2-like protein 7; SIR2L 7; SIR2L7; SIRT 7; SIR7_HUMAN; Sirtuin 7; Sirtuin type 7; Sirtuin7. |
| 产品应用 | Flow-Cyt=1μg/Test, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human SIRT7 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Oncoproteins/suppressors > Oncoproteins > Transcription factors Cardiovascular > Atherosclerosis > Apoptosis Cardiovascular > Heart > Cardiac metabolism Epigenetics and Nuclear Signaling > Chromatin Binding Proteins > DNA / RNA binding Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Acetylation > HDACs > Class III / Sir2 class Epigenetics and Nuclear Signaling > Transcription > Co-factors Epigenetics and Nuclear Signaling > Transcription > Polymerase associated factors > Pol I Transcription Metabolism > Pathways and Processes > Cofactors, Vitamins / minerals > Co-factors Metabolism > Pathways and Processes > Metabolic signaling pathways > Nucleotide metabolism > Purine and pyrimidine synthesis Metabolism > Types of disease > Heart disease |
| 亚基 | Interacts with UBTF and the RNA polymerase I complex. Interacts with histone H2A and/or histone H2B. |
| 亚细胞定位 | Cytoplasm. Nucleus, nucleolus. Note=Located close to the nuclear membrane when in the cytoplasm. Associated with chromatin. Associated with rDNA promoter and transcribed region. Associated with nucleolar organizer regions during mitosis. |
| 翻译后修饰 | Phosphorylated during mitosis (Probable). |
| 相似性 | Belongs to the sirtuin family. Class IV subfamily. Contains 1 deacetylase sirtuin-type domain. |
| 功能 | NAD-dependent protein deacetylase. Required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis. Promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | SIRT7 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {1μg/Test} |
| {IF} | {1:100-500} |
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文献和实验区、1个IgC样区、1个跨膜疏水区和1个由30个氨基酸组成的胞内区。不同于其他B7家族分子的是，它具有负向调节免疫应答的作用。PD-1和PD-L1是一对共抑制分子[3]。 这对共抑制分子，对癌细胞是如何发挥作用的呢。 憋急，听我慢慢道来！ 人类身体健康的卫士「T细胞」的活化是需要接收「双重信号」的：首先，T细胞表面受体（TCR）识别由抗原提呈细胞（APCs）提呈的抗原肽，使T细胞初步活化；然后，APC表面的共刺激分子与T细胞表面的相应共刺激分子结合，使T
上 loxP 重组位点，在特定 Cre 重组酶存在的情况下，loxP 两端之间的 DNA 就可被敲除，达到特定条件下灭活该基因的目的。应用这种模型的第一个成功例子是应用 Cre-loxP 系统介导的体细胞灭活 Apc 基因而构建的小鼠结直癌模型。应用腺病毒载体实现 Cre 重组酶特异性表达于肠上皮细胞，组织特异性敲除 APC 基因，引起小鼠快速形成散在结直腺瘤，其特征与家族性结肠腺瘤性息肉病（FAP）病人有许多相似性。所以，通过发现特异性相关癌症基因的突变体，研究者们可构建能更能模拟肿瘤病人在组织
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