SMYD3 | KMT3E Rabbit pAb, HRP conj.(bs-5974R-HRP)-100ul产品图

SMYD3 | KMT3E Rabbit pAb, HRP

conj.(bs-5974R-HRP)-100ul
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  • bs-5974R-HRP
  • 2026年10月17日
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    北京博奥森生物技术有限公司
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    • 规格：

      100ul

    产品编号bs-5974R-HRP
    英文名称SMYD3 Rabbit pAb, HRP conjugated
    中文名称HRP标记的组蛋白甲基转移酶SMYD3抗体
    英文别名SET and MYND domain containing 3; SET and MYND domain containing protein 3; SMYD 3; SMYD3 protein; Zinc finger MYND domain containing 1; Zinc finger MYND domain containing protein 1; Zinc finger protein subfamily 3A MYND domain containing 1; ZMYND 1; ZMYND1; ZNFN3A1; SMYD3_HUMAN.
    产品应用IHC-P=1:100-500, IHC-F=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human SMYD3
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Oncoproteins/suppressors > Oncoproteins > Transcription factors

    Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Methylation

    Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Methylation > Lysine methylation

    Epigenetics and Nuclear Signaling > Transcription > Polymerase associated factors > Pol II Transcription

    亚基Interacts with HSPCA. Interacts with HELZ. Interacts with POLR2A; the interaction may be indirect and may be mediated by HELZ. _x000D_
    亚细胞定位Cytoplasm. Nucleus. Note=Mainly cytoplasmic when cells are arrested at G0/G1. Accumulates in the nucleus at S phase and G2/M. _x000D_
    组织特异性Expressed in skeletal muscles and testis. Overexpressed in a majority of colorectal and hepatocellular carcinomas.
    相似性Belongs to the histone-lysine methyltransferase family.
    Contains 1 MYND-type zinc finger.
    Contains 1 SET domain.
    功能Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料SMYD3 is a gene that is over-expressed in the majority of colorectal carcinomas and hepatocellular carcinomas. SMYD3 forms a complex with RNA polymerase II through an interaction with the RNA helicase HELZ and transactivates a set of genes that included oncogenes, homeobox genes and genes associated with cell-cycle regulation. SMYD3 binds to a motif, 5'-CCCTCC-3', present in the promoter region of downstream genes such as Nkx2.8. The SET domain of SMYD3 shows histone H3-lysine 4 (H3-K4)-specific methyltransferase activity, which is enhanced in the presence of the heat-shock protein HSP90A.

     

    应用推荐稀释比例
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}

     

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