- ￥2980
- Bioss
- bs-5231R-BF350
- 2025年09月30日
- 产品信息以Bioss网站为准
企业认证
相关产品推荐更多 >
C-erbB-2/HER2 Mouse mAb, Cy7 conjugated(bsm-33051M-Cy7)-100ul
￥2980
N4BP1 Rabbit pAb, PE conjugated(bs-18984R-PE)-100ul
￥2980
PHLP Rabbit pAb, BF647 conjugated(bs-5812R-BF647)-100ul
￥2980
Bcl-2 Mouse mAb, Biotin conjugated(bsm-33413M-Bio)-100ul
￥2980Peroxiredoxin 1 Mouse mAb, Cy5 conjugated(bsm-33118M-Cy5)-100ul
￥2980
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 应用范围：
产品信息以Bioss网站为准
- 规格：
100ul
| 产品编号 | bs-5231R-BF350 |
| 英文名称 | phospho-Bid (Ser61) Rabbit pAb, BF350 conjugated |
| 中文名称 | BF350标记的磷酸化BH3结构域凋亡诱导蛋白抗体 |
| 英文别名 | Bid(phospho S61); p-Bid(phospho S61); BH3 interacting domain death agonist; p22 BID; BID; ) BH3-interacting domain death agonist; AltName: BH3-interacting domain death agonist p15; BH3-interacting domain death agonist p13; p13 BID; BH3-interacting domain death agonist p11; p11 BID. |
| 产品应用 | Flow-Cyt=0.2μg/Test Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated Synthesised phosphopeptide derived from mouse Bid around the phosphorylation site of Ser61 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Cell Death > Apoptosis > Apoptosis Markers > Bcl 2 family Cancer > Cell Death > Apoptosis > Metabolism Cancer > Cell Death > Apoptosis > Mitochondrial Cancer > Invasion/microenvironment > Apoptosis > Bcl 2 family Cell Biology > Apoptosis > Intracellular > Bcl2 Family Cell Biology > Apoptosis > Mitochondrial Metabolism > Pathways and Processes > Metabolism processes > Apoptosis Metabolism > Pathways and Processes > Mitochondrial Metabolism > Mitochondrial markers |
| 亚基 | Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2. |
| 亚细胞定位 | Cytoplasm (By similarity). Mitochondrion membrane. Note=When uncleaved, it is predominantly cytoplasmic. BH3-interacting domain death agonist p15: Mitochondrion membrane. Note=Translocates to mitochondria as an integral membrane protein. BH3-interacting domain death agonist p13: Mitochondrion membrane. Note=Associated with the mitochondrial membran. Isoform 1: Cytoplasm. Isoform 3: Cytoplasm. Isoform 2: Mitochondrion membrane. Note=A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively. |
| 组织特异性 | Isoform 2 and isoform 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 is expressed in spleen, pancreas and placenta (at protein level). Isoform 3 is expressed in lung, pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level). |
| 翻译后修饰 | TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products. _x000D_ Phosphorylated upon DNA damage, probably by ATM or ATR. |
| 功能 | The major proteolytic product p15 BID allows the release of cytochrome c. Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Bid, a BH3 domain containing proapoptotic Bcl2 family member, is localized in the cytosolic fraction of cells as an inactive precursor. Its active form is generated upon proteolytic cleavage by caspase 8 in the Fas signaling pathway. Cleaved Bid translocates to mitochondria and releases its potent proapoptotic activity, which in turn induces cytochrome c release and mitochondrial damage. The cytochrome c releasing activity of Bid was antagonized by Bcl2. Mutation in the SH3 domain can diminish the cytochrome c releasing activity. In animal model studies, Bid deficient mice are found resistant to the lethal effects of death factor signals relayed through Fas. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {0.2μg/Test} |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
phospho-Bid (Ser61) Rabbit pAb, BF350 conjugated(bs-5231R-BF350)-100ul
￥2980
