- ￥2980
- Bioss
- bs-4901R-AP
- 2025年09月30日
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100ul
| 产品编号 | bs-4901R-AP |
| 英文名称 | Annexin A7 Rabbit pAb, AP conjugated |
| 中文名称 | AP标记的膜粘连蛋白7抗体 |
| 英文别名 | Annexin VII; AnnexinVII; Annexin A7; ANX7; ANXA7; SNX; Synexin; Annexin-7; ANXA7_HUMAN. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Annexin A7 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Signal Transduction > Cytoskeleton / ECM > Cell Adhesion > Annexins Signal Transduction > Signaling Pathway > Calcium Signaling > Calcium Channels |
| 亚基 | Homodimer. Forms a ternary complex with NFE2L2 and PGAM5. Interacts with the N-terminal regulatory domain of NFE2L2/NRF2. Interacts with BPTF and PTMA. Interacts with CUL3. Part of a complex that contains KEAP1, CUL3 and RBX1. |
| 亚细胞定位 | Cytoplasm. Nucleus. Note=Shuttles between cytoplasm and nucleus. |
| 组织特异性 | Broadly expressed, with highest levels in skeletal muscle. |
| 相似性 | Contains 1 BACK (BTB/Kelch associated) domain. Contains 1 BTB (POZ) domain. Contains 6 Kelch repeats. |
| 功能 | Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The Annexins are a family of structurally similar proteins. Annexins bind to phospholipids and may be involved in regulation of membrane transport, membrane channel activity, and interaction of the cell membrane with the extracellular matrix. Annexin A7 is a member of the annexin family of calcium dependent phospholipid binding proteins. The Annexin A7 gene contains 14 exons and spans approximately 34 kb of DNA. Structural analysis of the protein suggests that Annexin A7 is a membrane binding protein with diverse properties including voltage sensitive calcium channel activity, ion selectivity and membrane fusion. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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Annexin A7 Rabbit pAb, AP conjugated(bs-4901R-AP)-100ul
￥2980
