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- bs-5289R-Bio
- 2025年09月30日
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100ul
| 产品编号 | bs-5289R-Bio |
| 英文名称 | phospho-DOK1 (Tyr362) Rabbit pAb, Biotin conjugated |
| 中文名称 | Biotin标记的磷酸化D酪氨酸激酶衰减蛋白1抗体 |
| 英文别名 | DOK1(phospho Y362); DOK1(phospho Tyr362); p-DOK1(phospho Y362); docking protein 1(downstream of tyrosine kinase 1); Docking protein 1(p62(dok))(Downstream of tyrosine kinase 1)(pp62).; docking protein 1 62kD(downstream of tyrosine kinase 1); Docking protein 1 62kD; Docking protein 1 62kD; Docking protein 1; DOK 1; DOK1; DOK-1; DOK1_HUMAN; Downstream of tyrosine kinase 1; p62(dok); P62DOK; pp62; pp62. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated Synthesised phosphopeptide derived from human DOK1 around the phosphorylation site of Tyr362 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Signal transduction Cancer > Signal transduction > Protein phosphorylation Cardiovascular > Blood > Platelets Metabolism > Types of disease > Obesity Signal Transduction > Adapters > Cytoplasmic Signal Transduction > Protein Phosphorylation > Tyrosine Kinases Signal Transduction > Signaling Pathway > Lipid Signaling |
| 亚基 | Interacts with ABL1. Interacts with RasGAP and INPP5D/SHIP1. Interacts directly with phosphorylated ITGB3. |
| 亚细胞定位 | Isoform 1: Cytoplasm. Isoform 3: Cytoplasm, perinuclear region. |
| 组织特异性 | Expressed in pancreas, heart, leukocyte and spleen. Expressed in both resting and activated peripheral blood T-cells. |
| 翻译后修饰 | Constitutively tyrosine-phosphorylated. Phosphorylated by TEC (By similarity). Phosphorylated by LYN. Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. Isoform 3 contains a N-acetylmethionine at position 1. |
| 相似性 | Belongs to the DOK family. Type A subfamily. Contains 1 IRS-type PTB domain. Contains 1 PH domain. |
| 功能 | DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Docking protein 1 is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. Docking protein 1 contains a putative pleckstrin homology domain at the amino terminus and ten PXXP SH3 recognition motifs. Docking protein 2 binds p120 (RasGAP) from CML cells. It has been postulated to play a role in mitogenic signaling. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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phospho-DOK1 (Tyr362) Rabbit pAb, Biotin conjugated(bs-5289R-Bio)-100ul
￥2980
