Dystrobrevin alpha Rabbit pAb, Cy7 conjugated(bs-23134R-Cy7)-100ul

Dystrobrevin alpha Rabbit pAb,

Cy7 conjugated(bs-23134R-Cy7)-100ul
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  • ¥2980
  • Bioss已认证
  • bs-23134R-Cy7
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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    • 规格

      100ul

    产品编号bs-23134R-Cy7
    英文名称Dystrobrevin alpha Rabbit pAb, Cy7 conjugated
    中文名称Cy7标记的肌营养蛋白α抗体
    英文别名DRP3; DTN; DTNA; Dystrophin related protein 3; FLJ96209; LVNC1; OTTHUMP00000163154; OTTHUMP00000163155; D18S892E; DTN-A; DTNA_HUMAN.
    产品应用IF=1:100-500, ICC/IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from mouse Dystrobrevin alpha
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Neuroscience > Cell Type Marker > Neuron marker > Synapse marker

    Signal Transduction > Cytoskeleton / ECM > Cell Adhesion > Tight Junctions

    亚基Homotetramer, and heterotetramer with CRMP1, DPYSL2, DPYSL4 or DPYSL5. Interacts with synaptic vesicle protein 2 and SH3A domain of intersectin.
    亚细胞定位Cytoplasm. Cell projection, growth cone. Note=Colocalizes with synaptic vesicle protein 2 in the central region of the growth cone.
    组织特异性Mainly expressed in heart and skeletal muscle. Also strongly expressed in fetal brain and spinal cord.
    翻译后修饰Phosphorylation on Ser-522 by DYRK2 promotes subsequent phosphorylation on Thr-509, Thr-514 and Ser-518 by GSK3.
    相似性Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily.
    功能Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration .
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Dystrobrevin alpha belongs to the dystrobrevin subfamily of the dystrophin family. It is a component of the dystrophin associated protein complex (DPC), which consists of dystrophin and several integral and peripheral membrane proteins, including dystroglycans, sarcoglycans, syntrophins and alpha and beta dystrobrevin. The DPC localizes to the sarcolemma and its disruption is associated with various forms of muscular dystrophy. Dystrobrevin alpha may be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. Mutations in Dystrobrevin alpha are associated with left ventricular noncompaction with congenital heart defects.

     

    应用推荐稀释比例
    {IF}{1:100-500}
    {ICC/IF}{1:100-500}

     

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