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- Bioss
- bs-12658R-AP
- 2025年09月30日
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100ul
| 产品编号 | bs-12658R-AP |
| 英文名称 | SNRP70 Rabbit pAb, AP conjugated |
| 中文名称 | AP标记的SNRP70蛋白抗体 |
| 英文别名 | RNPU1Z; Rnulp70; RPU1; Small nuclear ribonucleoprotein 70(U1); Small nuclear ribonucleoprotein 70kD polypeptide(RNP antigen); Small nuclear ribonucleoprotein 70kDa(U1); Small nuclear ribonucleoprotein 70kDa polypeptide(RNP antigen); snRNP70; Snrp 70; SNRP70; U1 70K; U1 small nuclear ribonucleoprotein 70 kDa; U1 small nuclear ribonucleoprotein polypeptide A; U1 snRNP 70 kDa; U170K; U1AP; U1AP1; U1RNP. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human SNRP70 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > Chromatin Binding Proteins > DNA / RNA binding Epigenetics and Nuclear Signaling > DNA / RNA > RNA Processing > Splicing Immunology > Immune System Diseases > Autoimmune |
| 亚基 | U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Interacts with SCNM1. Found in a pre-mRNA splicing complex with SFRS4, SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Found in a pre-mRNA exonic splicing enhancer (ESE) complex with SNRNP70, SNRPA1, SRRM1 and TRA2B/SFRS10. Interacts with dephosphorylated SFRS13A and SFPQ. Interacts with NUDT21/CPSF5, CPSF6, SCAF11, and ZRANB2. |
| 亚细胞定位 | Nuclear. |
| 翻译后修饰 | The N-terminus is blocked. _x000D_ Extensively phosphorylated on serine residues in the C-terminal region. |
| 相似性 | Contains 1 RRM (RNA recognition motif) domain. |
| 功能 | Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | SNRP70 is an RNA-binding protein that is a specific component of the U1 small nuclear ribonucleoprotein complex and constitutes the major anti-(U1) RNP autoimmune antigen. SNRP70 contains 1 RRM (RNA recognition motif) domain and mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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SNRP70 Rabbit pAb, AP conjugated(bs-12658R-AP)-100ul
￥2980
