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- Bioss
- bs-11795R-AP
- 2025年09月30日
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100ul
| 产品编号 | bs-11795R-AP |
| 英文名称 | VGF Rabbit pAb, AP conjugated |
| 中文名称 | AP标记的神经内分泌调节肽VGF抗体 |
| 英文别名 | NERP-1; Nerve growth factor inducible; Neuroendocrine regulatory peptide-1; Neurosecretory protein VGF; VGF; VGF_HUMAN. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human VGF |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Neuroscience > Endocrine system > Gonadotrophic axis Neuroscience > Neurology process > Neuroendocrinology > General neuroendocrinology Signal Transduction > Growth Factors/Hormones > Hormones |
| 亚细胞定位 | Secreted. Cytoplasmic vesicle, secretory vesicle. Note=Stored in secretory vesicles and then secreted, NERP peptides colocalize with vasopressin in the storage granules of hypothalamus. |
| 组织特异性 | Central and peripheral nervous systems, synthesized exclusively in neuronal and neuroendocrine cells. |
| 翻译后修饰 | Multiple peptides are derived from VGF, with activities in synaptic plasticity, antidepression, penile erection, autonomic activation, and increases in energy expenditure. |
| 功能 | May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system. _x000D_ NERP peptides are involved in the control of body fluid homeostasis by regulating vasopressin release. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. Nerve growth factor (NGF) is a peptide that plays a key role in the differentiation and survival of neurons in the peripheral nervous system (PNS) and the central nervous system (CNS). VGF is a peptide synthesized and secreted by neurons and is upregulated by NGF in the PC12 cell line. VGF is widely expressed in both the PNS and CNS, but is especially abundant in the adult hypothalamus. VGF plays an essential role in how the brain regulates energy expenditure and body weight. Its expression is rapidly induced by injury, the circadian clock, and neuronal activity. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
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VGF Rabbit pAb, AP conjugated(bs-11795R-AP)-100ul
￥2980
