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- Bioss
- bs-8506R-BF350
- 2025年09月30日
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100ul
| 产品编号 | bs-8506R-BF350 |
| 英文名称 | OSTM1 Rabbit pAb, BF350 conjugated |
| 中文名称 | BF350标记的骨硬化病相关跨膜蛋白1抗体 |
| 英文别名 | GAIP-interacting protein N terminus; GIPN; GL antibody Grey lethal osteopetrosis; HSPC019; OPTB5; Osteopetrosis-associated transmembrane protein 1; Ostm1; OSTM1_HUMAN. |
| 产品应用 | Flow-Cyt=1μg/Test Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human OSTM1 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Cell cycle > Cell differentiation Cell Biology > Cell Cycle > Cell differentiation Developmental Biology > Organogenesis > Skeletal development > Bone Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > Structures > Bone |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein. |
| 功能 | Required for osteoclast and melanocyte maturation and function (By similarity). |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | OSTM1 (osteopetrosis associated transmembrane protein 1), also known as gl (gray-lethal) or HSPC019, is a 338 amino acid single-pass type I membrane protein that is expressed primarily in osteoclasts and melanocytes as well as brain, kidney and spleen. Bone autosomal recessive osteopetrosis (ARO) is the most severe form of hereditary bone disease whose cellular basis is in the osteoclast and is characterized by abnormally dense bone, due to defective resorption of immature bone. ARO is suggested to be caused by mutations in the OSTM1 gene. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Defects in the OSTM1 gene are also the cause of the spontaneous gl mutant, which is responsible for a coat color defect in mice. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {1μg/Test} |
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OSTM1 Rabbit pAb, BF350 conjugated(bs-8506R-BF350)-100ul
￥2980
