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- bs-20831R-Bio
- 2025年09月30日
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100ul
| 产品编号 | bs-20831R-Bio |
| 英文名称 | NOXA1 Rabbit pAb, Biotin conjugated |
| 中文名称 | Biotin标记的NADPH氧化酶激活蛋白1抗体 |
| 英文别名 | Antigen NY CO 31; Antigen NY-CO-31; FLJ25475; Inhibitory NADPH oxidase activator 1; MGC131800; NADPH oxidase activator 1; NCF2 like protein; NCF2-like protein; NOX activator 1; NOXA 1; Noxa1; NOXA1_HUMAN; NY CO 31; p51 nox; p51-nox; p51NOX; P67phox like factor; P67phox-like factor; SDCCAG31; Serologically defined colon cancer antigen 31. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from mouse NOXA1 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Hypoxia > Associated Proteins Cell Biology > Other Antibodies > Oxidative Stress Metabolism > Pathways and Processes > Redox metabolism > Oxidative stress Signal Transduction > Protein Trafficking > Organelle Proteins |
| 亚基 | NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric complex supporting ROS production. Interaction with YWHAZ prevents the interaction of NOXA1 with NOXO1 and RAC1 and its targeting to membranes, hence reducing its ability to activate NOX1. Interacts (via N-terminus) with SH3PXD2A and SH3PXD2B; the interaction is direct._x000D_ |
| 亚细胞定位 | Cytoplasm. Cell membrane. Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1. |
| 组织特异性 | Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and colon. |
| 翻译后修饰 | Interaction with YWHAZ depends on phosphorylation by PKA. |
| 相似性 | Belongs to the NCF2/NOXA1 family. _x000D_ Contains 1 OPR domain. _x000D_ Contains 1 SH3 domain. _x000D_ Contains 4 TPR repeats. |
| 功能 | Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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NOXA1 Rabbit pAb, Biotin conjugated(bs-20831R-Bio)-100ul
￥2980
