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- bs-11849R-BF350
- 2025年09月30日
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100ul
| 产品编号 | bs-11849R-BF350 |
| 英文名称 | Gbx2 Rabbit pAb, BF350 conjugated |
| 中文名称 | BF350标记的肠和大脑特定同源蛋白2抗体 |
| 英文别名 | Gastrulation and brain-specific homeobox protein 2; Gastrulation brain homeo box 2; Gastrulation brain homeo box 2; gbx2; GBX2_HUMAN; Homeobox protein GBX 2; Homeobox protein GBX 2; Homeobox protein GBX-2; Homeobox protein STRA7; Mmoxa. |
| 产品应用 | Flow-Cyt=1μg/Test Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Gbx2 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > Transcription > Domain Families > Developmental Families Neuroscience > Neurology process > Neurogenesis |
| 亚基 | May act as a transcription factor for cell pluripotency and differentiation in the embryo. |
| 亚细胞定位 | Nucleus. |
| 相似性 | Contains 1 homeobox DNA-binding domain. |
| 功能 | May act as a transcription factor for cell pluripotency and differentiation in the embryo. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The isthmic organizer signals at the mid/hindbrain boundary (MHB) regulate the development and differentiation of the vertebrate caudal midbrain and the anterior hindbrain. The MHB forms at the boundary of expression between homeobox genes Gbx2 and Otx2. Gbx2 and Otx2 play distinct, essential roles in MHB positioning and development. During development, the GBX2 gene is expressed in the anterior hindbrain. Specifically, Gbx2 negatively regulates Otx2 expression along the anterior-posterior axis; Gbx2(-) mutants demonstrate an expanded Otx2 domain. During development, the GBX2 gene is expressed in the anterior hindbrain. Gbx2 is expressed in the adult brain, spleen and female genital tract. The GBX2 gene is over-expressed in human prostate cancer cell lines (TSU-prl, PC3, DU145 and LNCaP). Furthermore, downregulation of Gbx2 expression restricts tumorigenicity in human prostate cancer cell lines, which suggests that Gbx2 expression may be required for growth of malignant prostate cells. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {1μg/Test} |
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Gbx2 Rabbit pAb, BF350 conjugated(bs-11849R-BF350)-100ul
￥2980
