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- bs-18450R-HRP
- 2025年09月30日
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100ul
| 产品编号 | bs-18450R-HRP |
| 英文名称 | LXR beta Rabbit pAb, HRP conjugated |
| 中文名称 | HRP标记的肝脏X受体β抗体 |
| 英文别名 | Liver X nuclear receptor beta; Liver X receptor beta; Liver X receptor beta; LX receptor beta; LXR b; LXR beta; LXRB; NER 1; NER; NER I; NER1; NERI; NR1H 2; NR1H; NR1H2; NR1H2 protein; NR1H2_HUMAN; Nuclear orphan receptor LXR beta; Nuclear orphan receptor LXR beta; Nuclear receptor NER; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2; OR-1; Oxysterols receptor LXR beta; Oxysterols receptor LXR-beta; RIP 15; RIP15; steroid hormone nuclear receptor NER; Ubiquitously expressed nuclear receptor; Ubiquitously-expressed nuclear receptor; UENR; UNR. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human LXR beta |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Lipids / Lipoproteins > Lipid Metabolism > Cholesterol Metabolism Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > Nuclear Receptors > Orphan Nuclear Receptors Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Cholesterol Metabolism Metabolism > Types of disease > Cancer |
| 亚基 | Forms a heterodimer with RXR. |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Ubiquitous. |
| 相似性 | Belongs to the nuclear hormone receptor family. NR1 subfamily. _x000D_ Contains 1 nuclear receptor DNA-binding domain. |
| 功能 | Orphan receptor. Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010] |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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LXR beta Rabbit pAb, HRP conjugated(bs-18450R-HRP)-100ul
￥2980
