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- Bioss
- bs-11035R-Bio
- 2025年09月30日
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100ul
| 产品编号 | bs-11035R-Bio |
| 英文名称 | TNFAIP8L2 Rabbit pAb, Biotin conjugated |
| 中文名称 | Biotin标记的肿瘤坏死因子诱导蛋白8样蛋白2/TNFα-IP 8L2抗体 |
| 英文别名 | Tumor necrosis factor alpha-induced protein 8-like protein 2; Inflammation factor protein 20; TIPE2; TIPE 2; TIPE-2; TNF alpha-induced protein 8-like protein 2; TNFAIP8-like protein 2; TNFAIP8L2; TP8L2_HUMAN; Tumor necrosis factor alpha-induced protein 8-like protein 2; AW610835; FLJ23467. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human TNFAIP8L2/TIPE2 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚基 | May interact with CASP8; however, such result is unclearsince PubMed:19079267 could not reproduce the interaction withCASP8. |
| 组织特异性 | Expressed in spleen, thymus, small intestine and lymph node with lower levels present in colon, lung and skin |
| 相似性 | Belongs to the TNFAIP8 family. TNFAIP8L2 subfamily. |
| 功能 | Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Negative regulator of Toll-like receptor and T-cell receptor function. Prevents hyperresponsiveness of the immune system and maintains immune homeostasis. Inhibits JUN/AP1 and NF-kappa-B activation. Promotes Fas-induced apoptosis. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | TNF Alpha-IP 8L2 (tumor necrosis factor, alpha-induced protein 8-like 2), also known as TIPE2, is a 184 amino acid protein that shares 94% identity with its mouse counterpart and belongs to the TNFAIP8 family. Expressed in spleen, thymus, small intestine and lymph node with lower levels present in colon, lung and skin, TNF Alpha-IP 8L2 plays a role in maintaining immune homeostasis, specifically by acting as a negative regulator of both innate and adaptive immunity. In addition, TNF?IP 8L2 functions as a negative regulator of T-cell receptor function and is thought to promote Fas-induced apoptosis. The gene encoding TNF?IP 8L2 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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TNFAIP8L2 Rabbit pAb, Biotin conjugated(bs-11035R-Bio)-100ul
￥2980
