- ￥2980
- Bioss
- bs-20753R-Cy5.5
- 2025年09月30日
- 产品信息以Bioss网站为准
企业认证
相关产品推荐更多 >
ITGB4/CD104 Rabbit pAb, IRDye 800CW conjugated(bs-10028R-IRDye800CW)-100ul
￥2980
BTF3 Rabbit pAb, BF700 conjugated(bs-12900R-BF700)-100ul
￥2980
Fibulin 7 Rabbit pAb, RBITC conjugated(bs-13161R-RBITC)-100ul
￥2980
phospho-IRE1a (Ser 726) Rabbit pAb, Cy5 conjugated(bs-4308R-Cy5)-100ul
￥2980
Claudin 3 Rabbit pAb, Cy5 conjugated(bs-2788R-Cy5)-100ul
￥2980
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 应用范围：
产品信息以Bioss网站为准
- 规格：
100ul
| 产品编号 | bs-20753R-Cy5.5 |
| 英文名称 | SOCS3 Rabbit pAb, Cy5.5 conjugated |
| 中文名称 | Cy5.5标记的细胞因子信号传导抑制蛋白3抗体 |
| 英文别名 | suppressor of cytokine signaling 3; ATOD4; CIS 3; CIS3; Cish3; Cytokine induced SH2 protein 3; E2a Pbx1 target gene in fibroblasts 10; EF 10; MGC71791; SOCS 3; SOCS-3; SSI 3; SSI3; STAT induced STAT inhibitor 3; Suppressor of cytokine signaling 3; SOCS3_HUMAN. |
| 产品应用 | Flow-Cyt=1μg/Test, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human SOCS3 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Cancer Metabolism > Response to hypoxia Epigenetics and Nuclear Signaling > Nuclear Signaling Pathways > STATs Immunology > Innate Immunity > Cytokines > IL6 Related Metabolism > Pathways and Processes > Metabolism processes > Hypoxia Metabolism > Types of disease > Obesity Signal Transduction > Adapters > Cytoplasmic Stem Cells > Hematopoietic Progenitors > Intracellular Molecules |
| 亚基 | Interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1 receptor, insulin receptor and JAK2. Binding to JAK2 is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK2 JH1 domain. Binds specific activated tyrosine residues of the leptin, EPO, IL12, GSCF and gp130 receptors. Interaction with CSNK1E stabilizes SOCS3 protein. Component of the probable ECS(SOCS3) E3 ubiquitin-protein ligase complex which contains CUL5, RNF7/RBX2, Elongin BC complex and SOCS3. Interacts with CUL5, RNF7, TCEB1 and TCEB2. Interacts with CUL2. |
| 亚细胞定位 | Cytoplasm |
| 组织特异性 | Widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. Lower levels in thymus. |
| 翻译后修饰 | Phosphorylated on tyrosine residues after stimulation by the cytokines, IL-2, EPO or IGF1. |
| 相似性 | Contains 1 SH2 domain._x000D_
Contains 1 SOCS box domain. |
| 功能 | SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. Regulates IL-6 signaling in vivo (By similarity). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST (By similarity). |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Cytokines signal transduction pathway suppressor of cytokine signaling 3 positive cells in the brain are widely distributed, some of the cytoplasm of neurons, nerve fibers, glial cell line. suppressor of cytokine signaling 3 studies in recent years to prove: vascular endothelial cells also showed immune SOCS 3-positive. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {1μg/Test} |
| {IF} | {1:100-500} |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
SOCS3 Rabbit pAb, Cy5.5 conjugated(bs-20753R-Cy5.5)-100ul
￥2980
