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- bs-5125R-PerCP-Cy5.5
- 2025年09月30日
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100ul
| 产品编号 | bs-5125R-PerCP-Cy5.5 |
| 英文名称 | Frizzled 7 Rabbit pAb, PerCP-Cy5.5 conjugated |
| 中文名称 | PerCP-Cy5.5标记的卷曲蛋白FZD7抗体 |
| 英文别名 | Frizzled drosophila homolog of 7; Frizzled homolog 7; Frizzled7; Fz 7; Fz7; FZD 7; FZD7; FzE 3; FZE3; Frizzled 3; Frizzled3; Frizzled-3; hFz 7; hFz7; Homolog of Drosophila Frizzled 7. |
| 产品应用 | Flow-Cyt=3ug/Test Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Frizzled 7 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA and 0.02% Proclin300. |
| 亚基 | Interacts with MAGI3 and DVL1. |
| 亚细胞定位 | Membrane; Multi-pass membrane protein. |
| 组织特异性 | High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart, brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas. |
| 相似性 | Belongs to the G-protein coupled receptor Fz/Smo family._x000D_
Contains 1 FZ (frizzled) domain. |
| 功能 | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. |
| 保存条件 | Store at 2-8°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The Frizzled 7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Frizzled family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. Frizzled 7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. Frizzled 7 expression has been reported in brain, gastrointestinal tract, heart, fetal kidney, fetal lung, placenta, skeletal muscle, and various cancers. ESTs have been isolated from a wide variety of normal and cancer libraries. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {3ug/Test} |
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Frizzled 7 Rabbit pAb, PerCP-Cy5.5 conjugated(bs-5125R-PerCP-Cy5.5)-100ul
￥2980
