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- Bioss
- bs-12422R-AP
- 2025年09月30日
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100ul
| 产品编号 | bs-12422R-AP |
| 英文名称 | 14-3-3 sigma Rabbit pAb, AP conjugated |
| 中文名称 | AP标记的14-3-3 sigma抗体 |
| 英文别名 | 14 3 3 protein sigma; 14-3-3 protein sigma; 1433S_HUMAN; Epithelial cell marker protein 1; Er; HME 1; HME1; MGC143283; Mkrn3; Mme1; OTTHUMP00000004242; RP23 137L22.11; SFN; SFN protein; Stratifin; YWHAS. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human 14-3-3 sigma |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Neuroscience > Cell Type Marker > Neuron marker > Synapse marker Neuroscience > Neurology process > Neural Signal Transduction Signal Transduction > Adapters > Cytoplasmic Stem Cells > Signaling Pathways > Wnt > 14-3-3 |
| 亚基 | Homodimer. Interacts with KRT17 and SAMSN1 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with GAB2. Interacts with SRPK2. Interacts with COPS6. Interacts with RFWD2; this interaction leads to proteasomal degradation. |
| 亚细胞定位 | Cytoplasm. Nucleus. Secreted. May be secreted by a non-classical secretory pathway. |
| 组织特异性 | Present mainly in tissues enriched in stratified squamous keratinizing epithelium. |
| 相似性 | Belongs to the 14-3-3 family. |
| 功能 | Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. _x000D_ p53-regulated inhibitor of G2/M progression. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a cell cycle checkpoint protein. The encoded protein binds to translation and initiation factors and functions as a regulator of mitotic translation. In response to DNA damage this protein plays a role in preventing DNA errors during mitosis. [provided by RefSeq, Aug 2017] |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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14-3-3 sigma Rabbit pAb, AP conjugated(bs-12422R-AP)-100ul
￥2980
