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- 2025年10月01日
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- 规格：
25ul/50ul/100ul
| 规格： | 25ul | 产品价格： | ￥800.0 |
|---|---|---|---|
| 规格： | 50ul | 产品价格： | ￥1400.0 |
| 规格： | 100ul | 产品价格： | ￥2500.0 |
| 产品编号 | bsm-63278R |
| 英文名称 | phospho-Caveolin-1 (Y14) Recombinant Rabbit mAb |
| 中文名称 | 磷酸化细胞质膜微囊蛋白-1重组兔单抗 |
| 英文别名 | BSCL3; CAV; CAV1; Caveolin1; CGL3; LCCNS; PPH3; VIP21. |
| 产品应用 | WB=1:1000-2000 Not yet tested in other applications. |
| 交叉反应 | Human |
| 抗体来源 | Rabbit |
| 免疫原 | A synthesized peptide derived from human Caveolin 1 around the phosphorylation site of Y14 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Recombinant |
| 理论分子量 | 20 kDa |
| 实际分子量 | 23kDa |
| 储存液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 研究领域 | Cancer > Cancer Metabolism > Response to hypoxia Cancer > Tumor biomarkers Cardiovascular > Lipids / Lipoproteins > Lipid Metabolism > Cholesterol Metabolism Metabolism > Pathways and Processes > Metabolic signaling pathways > Lipid and lipoprotein metabolism > Cholesterol Metabolism Metabolism > Pathways and Processes > Metabolism processes > Hypoxia Signal Transduction > Protein Trafficking > Vesicle Transport > Coat Proteins Tags & Cell Markers > Subcellular Markers > Organelles > Caveolae and Clathrin |
| 亚基 | Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and syntaxin. Interacts with rotavirus A NSP4. Interacts (via the N-terminus) with DPP4; the interaction is direct. Interacts with CTNNB1, CDH1 and JUP. Interacts with BMX and BTK. |
| 亚细胞定位 | Golgi apparatus membrane;Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Membrane, caveola; Peripheral membrane protein. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae. |
| 组织特异性 | Expressed in muscle and lung, less so in liver, brain and kidney. |
| 翻译后修饰 | The initiator methionine for isoform Beta is removed during or just after translation. The new N-terminal amino acid is then N-acetylated._x000D_
Phosphorylated at Tyr-14 by ABL1 in response to oxidative stress. |
| 相似性 | Belongs to the caveolin family. |
| 功能 | May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. |
| 保存条件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:1000-2000} |
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