- ￥800 - 2500
- Bioss
- bsm-63224R
- 2025年10月01日
- 产品信息以Bioss网站为准
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- 详细信息
- 技术资料
- 应用范围：
产品信息以Bioss网站为准
- 规格：
25ul/50ul/100ul
| 规格： | 25ul | 产品价格： | ￥800.0 |
|---|---|---|---|
| 规格： | 50ul | 产品价格： | ￥1400.0 |
| 规格： | 100ul | 产品价格： | ￥2500.0 |
| 产品编号 | bsm-63224R |
| 英文名称 | phospho-MLKL (S358) Recombinant Rabbit mAb |
| 中文名称 | 磷酸化MLKL重组兔单抗 |
| 英文别名 | hMLKL; Mlkl. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 交叉反应 | Human |
| 抗体来源 | Rabbit |
| 免疫原 | A synthesized peptide derived from human MLKL around the phosphorylation site of S358 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Recombinant |
| 理论分子量 | 54 kDa |
| 实际分子量 | 54kDa |
| 储存液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 研究领域 | Cancer > Cell Death > Necroptosis Microbiology > Organism > Virus > RNA Virus > ssRNA positive strand virus > SARS Coronavirus Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > Other Kinases |
| 亚基 | Homotrimer; forms homotrimers on necroptosis induction. Interacts with RIPK3; the interaction is direct. Upon TNF-induced necrosis, forms in complex with PGAM5, RIPK1 and RIPK3. Within this complex, may play a role in the proper targeting of RIPK1/RIPK3 to its downstream effector PGAM5._x000D_ Subcellular Location : Cytoplasm. Cell membrane. Note=Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction._x000D_ Post-translational modifications : Phosphorylation by RIPK3 induces a conformational switch that is required for necroptosis. It also induces homotrimerization and localization to the plasma membrane. |
| 亚细胞定位 | Cytoplasm. Cell membrane. Note=Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction. |
| 翻译后修饰 | Phosphorylation by RIPK3 induces a conformational switch that is required for necroptosis. It also induces homotrimerization and localization to the plasma membrane. |
| 相似性 | Belongs to the protein kinase superfamily._x000D_
Contains 1 protein kinase domain. |
| 功能 | Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process. Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. Does not have protein kinase activity. |
| 保存条件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process.Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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phospho-MLKL (S358) Recombinant Rabbit mAb(bsm-63224R)-25ul/50ul/100ul
￥800 - 2500
