- ￥800 - 2500
- Bioss
- bsm-63219R
- 2025年10月01日
- 产品信息以Bioss网站为准
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产品信息以Bioss网站为准
- 规格：
25ul/50ul/100ul
| 规格： | 25ul | 产品价格： | ￥800.0 |
|---|---|---|---|
| 规格： | 50ul | 产品价格： | ￥1400.0 |
| 规格： | 100ul | 产品价格： | ￥2500.0 |
| 产品编号 | bsm-63219R |
| 英文名称 | MUC-4 Recombinant Rabbit mAb |
| 中文名称 | 粘蛋白4重组兔单抗 |
| 英文别名 | Ascites sialoglycoprotein 1; Ascites sialoglycoprotein 2; Ascites sialoglycoprotein; ASGP; ASGP-1; ASGP-2; Muc4; Mucin 4 cell surface associated; Mucin 4 tracheobronchial; Mucin-4 beta chain; Testis mucin. |
| 产品应用 | WB=1:1000-2000 Not yet tested in other applications. |
| 交叉反应 | Human |
| 抗体来源 | Rabbit |
| 免疫原 | A synthesized peptide derived from human Mucin 4 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Recombinant |
| 理论分子量 | 542 kDa |
| 实际分子量 | 120kDa |
| 储存液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 研究领域 | Cancer > Invasion/microenvironment > ECM > Extracellular matrix > MUC Cancer > Tumor biomarkers > Tumor antigens Cancer > Tumor immunology > Tumor-associated antigens Microbiology > Protein > Human Protein > Defensin Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Proteins > MUC |
| 亚基 | A heterodimeric complex, composed of a mucin-4 alpha chain and a cysteine-rich transmembrane mucin-4 beta chain. Mucin-4 beta chain interacts with ERBB2 via the EGF-like domain 1. In nonpolarized cells, associates with ERBB2 and ERBB3. |
| 亚细胞定位 | Membrane; Single-pass membrane protein (Potential). Secreted. Note=Isoforms lacking the Cys-rich region, EGF-like domains and transmembrane region are secreted. Secretion occurs by splicing or proteolytic processing._x000D_
Mucin-4 beta chain: Cell membrane; Single-pass membrane protein. Mucin-4 alpha chain: Secreted. Isoform 3, 17: Cell membrane; Single-pass membrane protein. Isoform 11, 15: Secreted. |
| 组织特异性 | Expressed in the thymus, thyroid, lung, trachea, esophagus, stomach, small intestine, colon, testis, prostate, ovary, uterus, placenta, and mammary and salivary glands. Expressed in carcinomas arising from some of these epithelia, such as lung cancers, squamous cell carcinomas of the upper aerodigestive tract, mammary carcinomas, biliary tract, colon, and cervix cancers. Minimally or not expressed in the normal pancreas or chronic pancreatitis, but is highly expressed in pancreatic tumors and pancreatic tumor cell lines. |
| 翻译后修饰 | Proteolytically cleaved into 2 chains, mucin-4 alpha chain and mucin-4 beta chain._x000D_
mucrnin-4 alpha chain is highly O-glycosylated._x000D_ mucin-4 beta chain is predominantly N-glycosylated. |
| 相似性 | Contains 1 AMOP domain._x000D_
Contains 2 EGF-like domains._x000D_ Contains 1 NIDO domain._x000D_ Contains 1 VWFD domain. |
| 功能 | May play a role in tumor progression. Ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. Has anti-adhesive properties. Seems to alter cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and in its ability to act as an intramembrane ligand for ERBB2. Plays an important role in cell proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. The MUC4-ERBB2 complex causes site-specific phosphorylation of the ERBB2 'Tyr-1248'. In polarized epithelilal cells segragates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. |
| 保存条件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Membrane-bound mucin, a family of highly glycosylated proteins that constitute the major component of the mucus, the slimy and viscous secretion covering epithelial surfaces.These glycoproteins play important roles in the protection of the epithelium and are implicated in epithelial renewal and differentiation. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:1000-2000} |
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MUC-4 Recombinant Rabbit mAb(bsm-63219R)-25ul/50ul/100ul
￥800 - 2500
