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TIMP-1 Recombinant Rabbit mAb(

bsm-62994R)-50ul/100ul/25ul
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  • ￥800 - 2500
  • Bioss已认证
  • bsm-62994R
  • 2025年10月01日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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    • 规格：

      50ul/100ul/25ul

    规格：50ul产品价格：￥1400.0
    规格：100ul产品价格：￥2500.0
    规格：25ul产品价格：￥800.0
    产品编号bsm-62994R
    英文名称TIMP-1 Recombinant Rabbit mAb
    中文名称金属蛋白酶组织抑制因子-1重组兔单抗
    英文别名EPO; EPA; TIMP1; CLGI.
    产品应用WB=1:500-2000, IHC-P=1:200-1000, IHC-F=1:200-1000, IF=1:200-1000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    交叉反应Human
    抗体来源Rabbit
    免疫原A synthesized peptide derived from human TIMP1
    亚型IgG
    性状Liquid
    纯化方法affinity purified by Protein A
    克隆类型Recombinant
    理论分子量23
    实际分子量26
    浓度1mg/ml
    储存液10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
    研究领域

    Cancer > Invasion/microenvironment > Angiogenesis > ECM enzymes > TIMPs

    Cancer > Invasion/microenvironment > ECM > Extracellular matrix > TIMPs

    Cardiovascular > Angiogenesis > Adhesion / ECM > Matrix Metalloproteinases > TIMP

    Cell Biology > Proteolysis / Ubiquitin > Protease inhibitors > Metalloprotease inhibitors > TIMPs

    Signal Transduction > Cytoskeleton / ECM > Extracellular Matrix > ECM Enzymes > TIMP1 / TIMP2

    亚细胞定位Secreted.
    翻译后修饰The activity of TIMP1 is dependent on the presence of disulfide bonds.
    相似性Belongs to the protease inhibitor I35 (TIMP) family.
    _x000D_ Contains 1 NTR domain.
    功能Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14.
    保存条件Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor.

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:200-1000}
    {IHC-F}{1:200-1000}
    {IF}{1:200-1000}

     

    产品细节图片1
    P‌‌araformaldehyde-fixed, paraffin embedded Human Lung Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with TIMP-1 Monoclonal Antibody, Unconjugated (bsm-62994R) at 1:500 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    产品细节图片2
    P‌‌araformaldehyde-fixed, paraffin embedded Human Liver Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with TIMP-1 Monoclonal Antibody, Unconjugated (bsm-62994R) at 1:500 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    产品细节图片3
    P‌‌araformaldehyde-fixed, paraffin embedded Human Colon Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with TIMP-1 Monoclonal Antibody, Unconjugated (bsm-62994R) at 1:500 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    产品细节图片4
    P‌‌araformaldehyde-fixed, paraffin embedded Human Thyroid Cancer; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with TIMP-1 Monoclonal Antibody, Unconjugated (bsm-62994R) at 1:500 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    产品细节图片5
    P‌‌araformaldehyde-fixed, paraffin embedded Human Prostate Tumor; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with TIMP-1 Monoclonal Antibody, Unconjugated (bsm-62994R) at 1:200 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    产品细节图片6
    P‌‌araformaldehyde-fixed, paraffin embedded Human Glioma; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with TIMP-1 Monoclonal Antibody, Unconjugated (bsm-62994R) at 1:500 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    产品细节图片7
    P‌‌araformaldehyde-fixed, paraffin embedded Human Pancreas; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with TIMP-1 Monoclonal Antibody, Unconjugated (bsm-62994R) at 1:500 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    产品细节图片8
    P‌‌araformaldehyde-fixed, paraffin embedded Human Colon; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; The section was incubated with TIMP-1 Monoclonal Antibody, Unconjugated (bsm-62994R) at 1:500 overnight at 4°C, followed by conjugation to the bs-0295G-HRP and DAB (C-0010) staining.
    产品细节图片9
    25 ug total protein per lane of various lysates (see on figure) probed with TIMP-1 monoclonal antibody, unconjugated (bsm-62994R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.

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