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- bsm-62560R
- 2025年10月01日
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产品信息以Bioss网站为准
- 规格：
50ul/100ul/25ul
| 规格： | 50ul | 产品价格： | ￥1400.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥2500.0 |
| 规格： | 25ul | 产品价格： | ￥800.0 |
| 产品编号 | bsm-62560R |
| 英文名称 | ABRAXAS1 Recombinant Rabbit mAb |
| 中文名称 | ABRAXAS1重组兔单抗 |
| 英文别名 | ABRA1; ABRAXAS; FAM175A. |
| 产品应用 | WB=1:1000-2000, ICC/IF=1:50-200, IP=1:20-50, Flow-Cyt=1:50-100 Not yet tested in other applications. |
| 交叉反应 | Human |
| 抗体来源 | Rabbit |
| 免疫原 | A synthesized peptide derived from human ABRAXAS1 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Recombinant |
| 理论分子量 | 47 |
| 实际分子量 | 50 |
| 储存液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA / RNA > DNA Damage & Repair > DNA Damage Response > BRCA1 |
| 亚基 | Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. In the complex, interacts directly with UIMC1/RAP80, BRCC3/BRCC36 and BRE/BRCC45. Interacts directly (when phosphorylated at Ser-406) with BRCA1. Binds polyubiquitin. |
| 亚细胞定位 | Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). |
| 翻译后修饰 | Phosphorylation of Ser-406 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT domain of BRCA1. Phosphorylated upon DNA damage, probably by ATM or ATR. |
| 相似性 | Belongs to the FAM175 family. Abraxas subfamily. |
| 功能 | Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1. |
| 保存条件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:1000-2000} |
| {ICC/IF} | {1:50-200} |
| {IP} | {1:20-50} |
| {Flow-Cyt} | {1:50-100} |
Western blot analysis of MCF7 cell lysate. Using ABRAXAS1 (bsm-62560R) monoclonal antibody at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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ABRAXAS1 Recombinant Rabbit mAb(bsm-62560R)-50ul/100ul/25ul
￥800 - 2500
