- ￥800 - 2500
- Bioss
- bsm-62425R
- 2025年10月01日
- 产品信息以Bioss网站为准
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产品信息以Bioss网站为准
- 规格：
50ul/100ul/25ul
| 规格： | 50ul | 产品价格： | ￥1400.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥2500.0 |
| 规格： | 25ul | 产品价格： | ￥800.0 |
| 产品编号 | bsm-62425R |
| 英文名称 | RCHY1 Recombinant Rabbit mAb |
| 中文名称 | 泛素连接酶重组兔单抗 |
| 英文别名 | ARNIP; CHIMP; hARNIP; hPirh2; PIRH2E; PIRH2F; RCHY1; RNF199; ZCHY; ZNF363. |
| 产品应用 | WB=1:500-2000, ICC/IF=1:50-200, IP=1:20-50 Not yet tested in other applications. |
| 交叉反应 | Human, Mouse |
| 抗体来源 | Rabbit |
| 免疫原 | A synthesized peptide derived from human RCHY1 |
| 亚型 | IgG |
| 性状 | Liquid |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Recombinant |
| 理论分子量 | 30 |
| 实际分子量 | 30 |
| 储存液 | 10mM phosphate buffered saline(pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| 研究领域 |
Cancer > Cell cycle > Cell cycle inhibitors > p53 pathway Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ubiquitin |
| 亚基 | Monomer and homodimer. Interacts with AR, p53/TP53, MDM2, HDAC1, KAT5, PLAG1, PLAGL2, CDKN1B, COPE, UBE2D2 and GORAB/NTKLBP1. |
| 亚细胞定位 | Nucleus. Nucleus speckle. Cytoplasm. |
| 组织特异性 | Detected in testis, liver, kidney and heart. |
| 翻译后修饰 | Subject to ubiquitination and proteasomal degradation. |
| 相似性 | Contains 1 CHY-type zinc finger._x000D_ Contains 1 CTCHY-type zinc finger._x000D_ Contains 1 RING-type zinc finger. |
| 功能 | Mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including p53/TP53, HDAC1 and CDKN1B. Preferentially acts on tetrameric p53/TP53. Increases AR transcription factor activity. Contributes to the regulation of CDKN1B and p53/TP53 levels, and thereby contributes to the regulation of the cell cycle progression. |
| 保存条件 | Store at 4℃ for short term. Store at -20℃ for long term. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {ICC/IF} | {1:50-200} |
| {IP} | {1:20-50} |
Western blot analysis of 293 cell lysate. Using RCHY1 (bsm-62425R) monoclonal antibody at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.
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RCHY1 Recombinant Rabbit mAb(bsm-62425R)-50ul/100ul/25ul
￥800 - 2500
