PINX1 | LPTS Rabbit pAb, PerCP-Cy5.5 conj.(bs-9594R-PerCP-Cy5.5)-100ul产品图

PINX1 | LPTS Rabbit pAb, PerCP

-Cy5.5 conj.(bs-9594R-PerCP-Cy5.5)-100ul
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  • ￥2980
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  • bs-9594R-PerCP-Cy5.5
  • 2026年10月14日
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    北京博奥森生物技术有限公司
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      100ul

    产品编号bs-9594R-PerCP-Cy5.5
    英文名称PINX-1 Rabbit pAb, PerCP-Cy5.5 conjugated
    中文名称PerCP-Cy5.5标记的端粒酶抑制因子PinX-1抗体
    英文别名67-11-3 protein; FLJ20565; Hepatocellular carcinoma-related putative tumor suppressor; Liver-related putative tumor suppressor; LPTL; LPTS; MGC8850; PIN2 interacting protein 1; Pin2-interacting protein X1; PIN2/TERF1-interacting telomerase inhibitor 1; PINX1; PINX1_HUMAN; Protein 67-11-3; TRF1-interacting protein 1.
    产品应用Flow-Cyt=2ug/Test, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human PINX-1
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA and 0.02% Proclin300.
    研究领域

    Epigenetics and Nuclear Signaling > DNA / RNA > DNA Synthesis > Topoisomerases

    亚基Interacts with MCRS1, TERT, TERF1, NCL/nucleolin, and the telomerase RNA.
    亚细胞定位Nucleus.
    组织特异性Ubiquitous; expressed at low levels.
    相似性Belongs to the PINX1 family.
    _x000D_ Contains 1 G-patch domain.
    功能Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor.
    保存条件Store at 2-8°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料PINX1 is a ubiquitously expressed protein that localizes to nucleoli and telomere speckles. PINX1 contains one G-patch domain and one telomeric inhibiting domain (TID) at its C-terminus. PINX1 interacts with the telomere protein TRF1 and the telomerase reverse transcriptase TERT. The TID domain of PINX1 specifically interacts with TERT and functions to inhibit its activity, thus participating in the regulation of telomerase activity. Overexpression of PINX1 leads to shortened telomeres, further supporting an inhibitory role of PINX1 on telomerase activity. The depletion of PINX1 significantly increases telomerase activity and may lead to tumorigenicity of cancer cells. This suggests that PINX1 acts as a tumor suppressor and can inhibit cell proliferation. In addition, PINX1 is involved in nucleolar RNA maturation.

     

    应用推荐稀释比例
    {Flow-Cyt}{2ug/Test}
    {IF}{1:100-500}

     

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