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- Bioss
- bs-12401R-AP
- 2025年09月30日
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100ul
| 产品编号 | bs-12401R-AP |
| 英文名称 | NLE1 Rabbit pAb, AP conjugated |
| 中文名称 | AP标记的NLE1蛋白抗体 |
| 英文别名 | FLJ10458; NLE 1; Nle; Notchless gene homolog; Notchless homolog 1(Drosophila); Notchless homolog 1; Notchless protein homolog 1; NLE1_HUMAN. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human NLE1 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Stem Cells > Signaling Pathways > Notch > Nuclear |
| 亚细胞定位 | Nuclear, nucleolus. |
| 相似性 | Belongs to the NLE1/RSA4 family. Contains 8 WD repeats. _x000D_ |
| 功能 | NLE1 (Notchless protein homolog 1) contains 8 WD repeats and may be involved in the Notch signaling pathway. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The Notch signaling pathway is an evolutionary conserved system that is involved in intracellular communication. Notch receptors play an important role in development and cell-fate decisions. Notchless is a loss-of-function mutant allele that encodes for protein NLE1 (notchless homolog 1). NLE1 is a 485 amino acid WD40-repeat protein that binds to the cytoplasmic domain of Notch, regulating its signaling activity in Drosophila melanogaster and in mice. Deletion of the NLE1 gene in mice during the early stages of development results in embryonic death, while gene deletion in the late stages of development leads to activation of a caspase-3-dependent apoptotic pathway. In plants, NLE1 is crucial for normal cellular growth and development. Under-expression during shoot proliferation causes pleiotropic defects such as delayed flowering and abnormal organ maturation. It may also play a role in 60S ribosomal subunit biogenesis in yeast. NLE1 contains eight WD40 domains and produces one isoform due to alternative splicing. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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NLE1 Rabbit pAb, AP conjugated(bs-12401R-AP)-100ul
￥2980
