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- Bioss
- bs-10287R-BF350
- 2025年09月30日
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100ul
| 产品编号 | bs-10287R-BF350 |
| 英文名称 | GADD34 Rabbit pAb, BF350 conjugated |
| 中文名称 | BF350标记的生长抑制DNA损伤基因34抗体 |
| 英文别名 | Growth arrest and DNA damage-inducible 34; Apoptosis associated protein; GADD 34; Growth arrest and DNA damage inducible 34; Growth arrest and DNA-damage-inducible 34; PPP1R15A; Protein phosphatase 1 regulatory(inhibitor) subunit 15A; Protein phosphatase 1 regulatory subunit 15A; Apoptosis associated protein; GADD 34; Growth arrest and DNA damage inducible 34; Growth arrest and DNA damage-inducible protein GADD34; Myeloid differentiation primary response protein MyD116 homolog; Ppp1r15a; PR15A_HUMAN; Protein phosphatase 1 regulatory(inhibitor) subunit 15A; Protein phosphatase 1 regulatory subunit 15A. |
| 产品应用 | Flow-Cyt=1μg/Test Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human GADD34 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cell Biology > Cell Cycle > Kinases/Phosphatases > Phosphatases Epigenetics and Nuclear Signaling > Cell cycle > Kinases/Phosphatases > Phospatases Epigenetics and Nuclear Signaling > DNA / RNA > DNA Damage & Repair > DNA Damage Response |
| 亚基 | Interacts with PCNA (By similarity). Interacts with LYN and MLL. Interacts with PP1, PPP1R1A and SMARCB1. Interacts with SMAD7. Interacts with BAG1. |
| 亚细胞定位 | Endoplasmic reticulum. |
| 翻译后修饰 | Phosphorylated on tyrosine by LYN; which impairs its antiproliferative activity. |
| 相似性 | Belongs to the PPP1R15 family. |
| 功能 | Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation. [provided by RefSeq, Jul 2008] |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {1μg/Test} |
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GADD34 Rabbit pAb, BF350 conjugated(bs-10287R-BF350)-100ul
￥2980
