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- Bioss
- bs-12371R-AP
- 2025年09月30日
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100ul
| 产品编号 | bs-12371R-AP |
| 英文名称 | Kindlin 2 Rabbit pAb, AP conjugated |
| 中文名称 | AP标记的丝裂原诱导蛋白2抗体 |
| 英文别名 | FLJ34213; FLJ44462; UNC112; FERM2_HUMAN; Fermitin family homolog 2; Fermt2; KIND2; Kindlin-2; MIG-2; MIG2; Mitogen-inducible gene 2 protein; PH domain-containing family C member 1; Pleckstrin homology domain containing family C(with FERM domain) member 1; Pleckstrin homology domain-containing family C member 1; PLEKHC1; UNC112B. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Kindlin 2/MIG2 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Signal Transduction > Cytoskeleton / ECM > Cell Adhesion > Integrins > Beta Stem Cells > Mesenchymal Stem Cells > Myogenesis |
| 亚基 | Interacts with FBLP1. |
| 亚细胞定位 | Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Note=Within actin stress fibers at cell-ECM focal adhesion sites. |
| 组织特异性 | Ubiquitous. Found in numerous tumor tissues. |
| 相似性 | Belongs to the kindlin family. _x000D_ Contains 1 FERM domain. _x000D_ Contains 1 PH domain. |
| 功能 | Participates in the connection between ECM adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits migfilin (FBLP1) protein to cell-ECM focal adhesion sites. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Mig-2 recruits migfilin to cell-matrix adhesions, while the interaction with filamin mediates the association of migfilin with actin filaments. Together, Mig-2, migfilin and filamin define a connection between cell matrix adhesions and the actin cytoskeleton and participate in the orchestration of actin assembly and cell shape modulation. Mig-2 expression is transcriptionally elevated in leiomyomas and could be involved in its hormone-mediated growth of leiomyomas of the uterus. Expression of Mig-2 is ubiquitous, and it is found in numerous tumor tissues. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
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Kindlin 2 Rabbit pAb, AP conjugated(bs-12371R-AP)-100ul
￥2980
