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- Bioss
- bs-10727R-BF680
- 2025年09月30日
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100ul
| 产品编号 | bs-10727R-BF680 |
| 英文名称 | CD101 Rabbit pAb, BF680 conjugated |
| 中文名称 | BF680标记的CD101抗体 |
| 英文别名 | IGSF2; Immunoglobulin superfamily member 2; Leukocyte surface protein; V7; V7 LSB; IGSF2_HUMAN; IgSF2; Cell surface glycoprotein V7; Glu-Trp-Ile EWI motif-containing protein 101; EWI-101; CD101. |
| 产品应用 | Flow-Cyt=1μg/Test, IF=1:10-100 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human CD101 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Immunology > Adaptive Immunity > T Cells > CD |
| 亚细胞定位 | Membrane; Single-pass type I membrane protein (Potential). |
| 组织特异性 | Expressed in lung, thymus and small intestine. Detected in cutaneous dendritic cells, activated T-cells, monocytes and granulocytes as well as with epithelial cells with dendritic morphology. Expressed in some leukemic cells, the CD4(+) CD56(+) blastic tumor cells, as well as in Langerhans cells from LCH (Langerhans cell histiocytosis) patients. |
| 翻译后修饰 | N-glycosylated. |
| 相似性 | Contains 7 Ig-like C2-type (immunoglobulin-like) domains. |
| 功能 | Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | CD101 is a disulfide-linked homodimeric type 1 glycoprotein. The peptide is comprised of 7 extracellular V-type IgSF domains. CD101 is highly expressed on monocytes, granulocytes, mucosal T cells, and on activated peripheral blood T cells. Expression is weak on resting T and B and NK cells, absent from platelets and weak or absent from most hematopoietic cell lines. CD101 is thought to play a co-stimulatory role in TCR/CD3-mediated T cell activation. Monoclonal antibodies against CD101 inhibit allogeneic T cell responses. Studies suggest that CD101 plays a major role in the activation of T cells by skin dendritic cells. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {1μg/Test} |
| {IF} | {1:10-100} |
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CD101 Rabbit pAb, BF680 conjugated(bs-10727R-BF680)-100ul
￥2980
