- ￥2980
- Bioss
- bs-0497R-Cy3
- 2025年09月30日
- 产品信息以Bioss网站为准
企业认证
相关产品推荐更多 >
HMGN2/HMG17 Rabbit pAb, HRP conjugated(bs-18054R-HRP)-100ul
￥2980
Egr1 Rabbit pAb(bs-1076R)-50ul/100ul/200ul
￥1180Angiotensin III Rabbit pAb, PerCP-Cy5.5 conjugated(bs-20101R-PerCP-Cy5.5)-100ul
￥2980PCNA Rabbit pAb, BF488 conjugated(bs-2007R-BF488)-100ul
￥2980FLII Rabbit pAb, AP conjugated(bs-7864R-AP)-100ul
￥2980
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 应用范围：
产品信息以Bioss网站为准
- 规格：
100ul
| 产品编号 | bs-0497R-Cy3 |
| 英文名称 | Dnmt3a Rabbit pAb, Cy3 conjugated |
| 中文名称 | Cy3标记的DNA甲基转移酶-3α抗体 |
| 英文别名 | DNA(cytosine 5 ) methyltransferase 3 alpha; DNA(cytosine 5) methyltransferase 3A; DNA cytosine methyltransferase 3A2; DNA methyltransferase 3a; DNA methyltransferase HsaIIIA; DNA MTase HsaI; DNA MTase HsaIIIA; DNMT 3a; DNMT; DNMT3A2; M HsaIIIA; M.HsaIIIA; MCMT; Methyl CpG binding domain protein 3a. |
| 产品应用 | Flow-Cyt=1ug/Test, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Dnmt3a |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Epigenetics and Nuclear Signaling > DNA methylation > DNMTs |
| 亚基 | Heterotetramer composed of 1 DNMT3A homodimer and 2 DNMT3L subunits (DNMT3L-DNMT3A-DNMT3A-DNMT3L). Interacts with UBC9, PIAS1 and PIAS2. Binds the ZNF238 transcriptional repressor. Interacts with SETDB1. Associates with HDAC1 through its ADD domain. Interacts with DNMT1 and DNMT3B. Interacts with the PRC2/EED-EZH2 complex. Interacts with MPHOSPH8. Interacts with histone H3 that is not methylated at 'Lys-4' (H3K4). |
| 亚细胞定位 | Nucleus. Cytoplasm. Note=Accumulates in the major satellite repeats at pericentric heterochromatin. |
| 组织特异性 | Highly expressed in fetal tissues, skeletal muscle, heart, peripheral blood mononuclear cells, kidney, and at lower levels in placenta, brain, liver, colon, spleen, small intestine and lung. |
| 翻译后修饰 | Sumoylated; sumoylation disrupts the ability to interact with histone deacetylases (HDAC1 and HDAC2) and repress transcription. |
| 相似性 | Belongs to the C5-methyltransferase family._x000D_
Contains 1 ADD domain._x000D_ Contains 1 GATA-type zinc finger._x000D_ Contains 1 PHD-type zinc finger._x000D_ Contains 1 PWWP domain. |
| 功能 | Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016] |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {1ug/Test} |
| {IF} | {1:100-500} |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
Dnmt3a Rabbit pAb, Cy3 conjugated(bs-0497R-Cy3)-100ul
￥2980
