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- Bioss
- bs-7532R-AP
- 2025年09月30日
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100ul
| 产品编号 | bs-7532R-AP |
| 英文名称 | Islet 1 Rabbit pAb, AP conjugated |
| 中文名称 | AP标记的胰岛素基因增强结合蛋白1抗体 |
| 英文别名 | Insulin gene enhancer protein ISL 1; Insulin gene enhancer protein ISL-1; Insulin related protein; Isl 1; ISL LIM homeobox 1; ISL1; ISL1 transcription factor LIM homeodomain; ISL1 transcription factor, LIM/homeodomain(islet 1); ISL1 transcription factor, LIM/homeodomain; ISL1_HUMAN; Islet-1; Islet1. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human Islet 1 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Atherosclerosis > Diabetes associated Cardiovascular > Heart > Cardiogenesis > Transcription factors/regulators Developmental Biology > Lineage specification > Endoderm Developmental Biology > Organogenesis > Gut development > Pancreas development Neuroscience > Cell Type Marker > Neuron marker > Soma marker Neuroscience > Neurology process > Neurogenesis Stem Cells > Lineage Markers > Endoderm Stem Cells > Neural Stem Cells > Intracellular Stem Cells > Neural Stem Cells > Neuron Restricted Lineage |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain. |
| 相似性 | Contains 1 homeobox DNA-binding domain. _x000D_ Contains 2 LIM zinc-binding domains. |
| 功能 | Binds to one of the cis-acting domain of the insulin gene enhancer. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Islet-1 and Islet-2 contain amino-terminal LIM domains and a carboxy-terminal homeodomain and both influence developmental events. Islet-1 influences embryogenesis of the pancreatic islets of Langerhans and neural tube motor neuron differentiation. In developing mouse teeth, Islet-1 mediates patterning of dentition as an activator of Bmp4 expression in incisor (distal) areas of the stomatodeal epithelium. Islet-1 expression defines cardiac progenitor cell populations and is required for normal cardiac development and asymmetry. Islet-2 activity in newly generated motor neurons permits the diversification of visceral and somatic motor neuron subtypes in the developing spinal cord. Murine Islet-2 specifies retinal ganglion cell (RGC) laterality by repressing an ipsilateral pathfinding program unique to the ventral-temporal crescent (VTC) of RGCs in a Zic2- and EphB1-dependent manner. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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