- ￥2980
- Bioss
- bs-13960R-HRP
- 2025年09月30日
- 产品信息以Bioss网站为准
企业认证
相关产品推荐更多 >
ZNF229 Rabbit pAb, Biotin conjugated(bs-7189R-Bio)-100ul
￥2980phospho-MAK (Tyr159) Rabbit pAb, Biotin conjugated(bs-18634R-Bio)-100ul
￥2980
GATA4 Rabbit pAb(bs-1778R)-50ul/100ul/200ul
￥1180TPH2 Rabbit pAb, HRP conjugated(bs-8729R-HRP)-100ul
￥2980BCL2L1 Rabbit pAb, Cy7 conjugated(bs-1336R-Cy7)-100ul
￥2980
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 技术资料
- 应用范围：
产品信息以Bioss网站为准
- 规格：
100ul
| 产品编号 | bs-13960R-HRP |
| 英文名称 | GEP100/IQSEC1 Rabbit pAb, HRP conjugated |
| 中文名称 | HRP标记的ADP-核糖基化因子鸟嘌呤核苷酸交换蛋白100抗体 |
| 英文别名 | ADP-ribosylation factors guanine nucleotide-exchange protein 100; ADP-ribosylation factors guanine nucleotide-exchange protein 2; ARF GEP100; ARFGEP100; BRAG2; Brefeldin A resistant ARF GEF2; Brefeldin-resistant Arf-GEF 2 protein; GEP100; IQ motif and Sec7 domain 1; IQ motif and SEC7 domain-containing protein 1; IQEC1_HUMAN; Iqsec1; Kiaa0763. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human GEP100 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Signal transduction > G protein signaling > Small G proteins Signal Transduction > Signaling Pathway > G Protein Signaling > Small G Proteins > Regulators |
| 亚细胞定位 | Cytoplasm. Nucleus. At steady state, may be preferentially cytosolic. |
| 组织特异性 | Expressed in brain, ovary, heart, lung, liver, kidney and leukocytes. Moderate expression was also detected in lung, skeletal muscle, placenta, small intestine, pancreas, spleen and testis. |
| 相似性 | Belongs to the BRAG family. _x000D_ Contains 1 IQ domain. _x000D_ Contains 1 PH domain. _x000D_ Contains 1 SEC7 domain. |
| 功能 | In addition to accelerate GTP gamma S binding by ARFs of all three classes, it appears to function preferentially as a guanine nucleotide exchange protein for ARF6, mediating internalisation of beta-1 integrin. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The ADP-ribosylation factor (ARF) protein family are structurally and functionally conserved members of the Ras superfamily of regulatory GTP-binding proteins. ARFs influence vesicle trafficking and signal transduction in eukaryotic cells. ARF6 plays a role in protein trafficking near the plasma membrane, including receptor recycling, cell adhesion and cell migration. ARF6 colocalizes with the ARF guanine nucleotide-exchange protein (GEP) BRAG2, also designated GEP100. BRAG2 is ubiquitously expressed as two isoforms, BRAG2a and BRAG2b, which can cycle between the cytoplasm and the nucleus. BRAG2, via its interaction with ARF6, is involved in the regulation of cell adhesion by controlling Integrin ∫1 endocytosis and E-cadherin redistribution. BRAG2 has also been shown to bind directly to Tyr1068/1086-phosphorylated EGFR to activate ARF6, which induces tumor invasion in MCF7 cells. Therefore, BRAG2 may contribute to the metastasis and malignancy of some breast cancer cells. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
技术资料暂无技术资料 索取技术资料
GEP100/IQSEC1 Rabbit pAb, HRP conjugated(bs-13960R-HRP)-100ul
￥2980
