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- bs-13293R-Bio
- 2025年09月30日
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100ul
| 产品编号 | bs-13293R-Bio |
| 英文名称 | phospho-GATA2 (Ser401) Rabbit pAb, Biotin conjugated |
| 中文名称 | Biotin标记的磷酸化GATA结合蛋白2抗体 |
| 英文别名 | GATA2(phospho S401); p-GATA2(phospho S401); GATA-2; GATA 2; GATA Binding Protein 2; GATA-binding protein 2; Gata2; GATA2_HUMAN; MGC2306; NFE 1B; NFE1B. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthesised phosphopeptide derived from human GATA2 around the phosphorylation site of Ser401 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Heart > Cardiogenesis > Transcription factors/regulators Developmental Biology > Lineage specification > Ectoderm Epigenetics and Nuclear Signaling > Transcription > Domain Families > Zinc Finger Stem Cells > Lineage Markers > Ectoderm |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Endothelial cells. |
| 相似性 | Contains 2 GATA-type zinc fingers. |
| 功能 | Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Members of the GATA family share a conserved zinc finger DNA-binding domain and are capable of binding the WGATAR consensus sequence. GATA-1 is erythroid-specific and is responsible for the regulated transcription of erythroid genes. It is an essential component in the generation of the erythroid lineage. GATA-2 is expressed in embryonic brain and liver, HeLa and endothelial cells, as well as in erythroid cells. Studies with a modified GATA consensus sequence, AGATCTTA, have shown that GATA-2 and GATA-3 recognize this mutated consensus while GATA-1 has poor recognition of this sequence. This indicates broader regulatory capabilities of GATA-2 and GATA-3 than GATA-1. GATA-3 is highly expressed in T lymphocytes. GATA-4, GATA-5 and GATA-6 comprise a subfamily of transcription factors. Both GATA-4 and GATA-6 are found in heart, pancreas and ovary; lung and liver tissues exhibit GATA-6, but not GATA-4 expression. GATA-5 expression has been observed in differentiated heart and gut tissues and is present throughout the course of development in the heart. Although expression patterns of the various GATA transcription factors may overlap, it is not yet apparent how the GATA factors are able to discriminate in binding their appropriate target sites. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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phospho-GATA2 (Ser401) Rabbit pAb, Biotin conjugated(bs-13293R-Bio)-100ul
￥2980
