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- bs-8869R-PerCP-Cy5.5
- 2025年09月30日
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100ul
| 产品编号 | bs-8869R-PerCP-Cy5.5 |
| 英文名称 | IP3 receptor Rabbit pAb, PerCP-Cy5.5 conjugated |
| 中文名称 | PerCP-Cy5.5标记的5-三磷酸肌醇受体1抗体 |
| 英文别名 | Type 1 inositol 1 4 5 trisphosphate receptor; Type 1 inositol 1; Type 1 InsP3 receptor.; 5-trisphosphate receptor; 5-trisphosphate receptor type 1; DKFZp313E1334; DKFZp313N1434; inositol 1 4 5 triphosphate receptor type 1; Inositol 1 4 5 trisphosphate Receptor Type 1; Inositol 1; Inositol 145-trisphosphate Receptor Type 1; InsP3R1; IP3; IP3 receptor; IP3 receptor isoform 1; IP3R 1; IP3R; IP3R1; ITPR 1; Itpr1; ITPR1_HUMAN; SCA15; SCA16; SCA29; ACV; CLA4; INSP3R1. |
| 产品应用 | Flow-Cyt=2ug/Test, ICC/IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human IP3R 1 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA and 0.02% Proclin300. |
| 研究领域 | Cancer > Cancer Metabolism > Response to hypoxia Metabolism > Pathways and Processes > Metabolism processes > Hypoxia Metabolism > Types of disease > Cancer Signal Transduction > Signaling Pathway > Calcium Signaling |
| 亚基 | Homotetramer. Interacts with TRPC4. The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3. Interacts with ERP44 in a pH-, redox state- and calcium-dependent manner which results in the inhibition the calcium channel activity. The strength of this interaction inversely correlates with calcium concentration. Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1. Interacts with AHCYL1 (By similarity). Interacts with MRVI1 and CABP1 (via N-terminus). |
| 亚细胞定位 | Endoplasmic reticulum membrane. |
| 组织特异性 | Widely expressed. |
| 翻译后修饰 | Phosphorylated by cAMP kinase. Phosphorylation prevents the ligand-induced opening of the calcium channels. _x000D_ Phosphorylated on tyrosine residues. |
| 相似性 | Belongs to the InsP3 receptor family. _x000D_ Contains 5 MIR domains. |
| 功能 | Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate. |
| 保存条件 | Store at 2-8°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009] |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {2ug/Test} |
| {ICC/IF} | {1:100-500} |
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IP3 receptor Rabbit pAb, PerCP-Cy5.5 conjugated(bs-8869R-PerCP-Cy5.5)-100ul
￥2980
