Kidins220 Rabbit pAb, PerCP conjugated(bs-7040R-PerCP)-100ul

Kidins220 Rabbit pAb, PerCP co

njugated(bs-7040R-PerCP)-100ul
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  • ￥2980
  • Bioss已认证
  • bs-7040R-PerCP
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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      100ul

    产品编号bs-7040R-PerCP
    英文名称Kidins220 Rabbit pAb, PerCP conjugated
    中文名称PerCP标记的220kDa蛋白激酶D相互作用蛋白抗体
    英文别名Ankyrin repeat-rich membrane-spanning protein; arms; KDIS_HUMAN; Kidins220; Kinase D interacting substance of 220 kDa; Kinase D-interacting substrate of 220 kDa; rgd 619949.
    产品应用Flow-Cyt=1ug/Test, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human Kidins220
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA and 0.02% Proclin300.
    研究领域

    Cardiovascular > Angiogenesis > Ephrins > Eph Receptors

    Neuroscience > Neurotransmission > Intracellular Signaling > Kinases

    Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > Other Kinases

    亚基nteracts with NTRK1, NTRK2, NTRK3, ERKL and NGFR. Canform a ternary complex with NGFR and NTRK1 and this complex isaffected by the expression levels of KIDINS220/ARMS. An increase inKIDINS220/ARMS expression leads to a decreased association of NGFRand NTRK1. Interacts with SNTA1 and SNTB2 and binds to their PDZdomains. Interacts with EPHA4 and PRKD1 (By similarity).
    亚细胞定位Membrane.
    组织特异性Abundant in developing and adult neural tissues as well as neuroendocrine cells and dendritic cells. Overexpressed in melanoma and melanoma cell lines.
    翻译后修饰Tyrosine phosphorylated by NTRK1, NTRK2, EPHB2 and EPHA4.Phosphorylation at Ser-918 is induced by phorbol ester treatment.Phosphorylation by NTRK2 is induced by brain-derived neurotrophicfactor (BDNF) and neurotrophin-4/5. Phosphorylation by NTRK1 isinduced by nerve growth factor (NGF) (By similarity).
    相似性Contains 12 ANK repeats.
    Contains 1 KAP NTPase domain.
    功能’Promotes a prolonged MAP-kinase signaling byneurotrophins through activation of a Rap1-dependent mechanism.Provides a docking site for the CRKL-C3G complex, resulting inRap1-dependent sustained ERK activation. May play an important rolein regulating postsynaptic signal transduction through thesyntrophin-mediated localization of receptor tyrosine kinases suchas EPHA4. In cooperation with SNTA1 can enhance EPHA4-inducedJAK/STAT activation. May play a role in neurotrophin- andephrin-mediated neuronal outgrowth and in axon guidance duringneural development and in neuronal regeneration (By similarity).Modulates stress-induced apoptosis of melanoma cells via regulationof the MEK/ERK signaling pathway.
    保存条件Store at 2-8°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway.

     

    应用推荐稀释比例
    {Flow-Cyt}{1ug/Test}
    {IF}{1:100-500}

     

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