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- Bioss
- bs-22521R-HRP
- 2025年09月30日
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100ul
| 产品编号 | bs-22521R-HRP |
| 英文名称 | MNX1/HLXB9 Rabbit pAb, HRP conjugated |
| 中文名称 | HRP标记的运动神经元及胰腺同源蛋白1抗体 |
| 英文别名 | HB9/HLXB9; HB 9; HB9; HLXB 9; HLXB9; Homeo box HB9; Homeobox HB9; Homeobox protein HB9; HOXHB9; MNX1; MNX1_HUMAN; Motor neuron and pancreas homeobox protein 1; Sacral agenesis autosomal dominant(Currarino triad); SCRA 1; SCRA1; SCRA1; HOXHB9. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human MNX1/HLXB9 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Developmental Biology > Lineage specification > Ectoderm Epigenetics and Nuclear Signaling > Transcription > Domain Families > Developmental Families Neuroscience > Cell Type Marker > Neuron marker > Soma marker Stem Cells > Lineage Markers > Ectoderm Stem Cells > Neural Stem Cells > Neuron Restricted Lineage |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Expressed in lymphoid and pancreatic tissues. |
| 相似性 | Contains 1 homeobox DNA-binding domain. |
| 功能 | Putative transcription factor involved in pancreas development and function. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The HB9 homeobox transcription factor regulates gene expression during embryonic development and also in specific adult tissues. HB9 gene mutations are implicated in Curriano syndrome, which is characterized by a triad consisting of a presacral tumor, sacral agenesis and anorectal malformation. In human bone marrow cells, HB9 expression directly correlates with CD34 expression. Furthermore, HB9 expression increases in CD34+ cells that are treated with IL-3 and granulocyte macrophage-colony-stimulating factor. Early in murine development, HB9 is expressed in pancreatic buds (dorsal and ventral) with subsequent expression in differentiating beta cells in the islets of Langerhans. The dorsal lobe of the pancreas fails to form in HB9(-) mice; the resultant pancreas has smaller islets of Langerhans and less beta cells than normal pancreas. The HB9 gene is expressed in the human adult pancreas. In the developing vertebrate embryo, the HB9 gene plays an essential role in motor neuron differentiation. The motor columns of HB9(-) mice are disorganized, lacking phrenic and abducens nerves and exhibiting intercostal nerve defects. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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MNX1/HLXB9 Rabbit pAb, HRP conjugated(bs-22521R-HRP)-100ul
￥2980
