TNF alpha Rabbit pAb, BF680 conjugated(bs-10802R-BF680)-100ul

TNF alpha Rabbit pAb, BF680 co

njugated(bs-10802R-BF680)-100ul
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  • bs-10802R-BF680
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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      100ul

    产品编号bs-10802R-BF680
    英文名称TNF alpha Rabbit pAb, BF680 conjugated
    中文名称BF680标记的肿瘤坏死因子-α/TNFα/TNF-α抗体
    英文别名Tumor necrosis factor-α; TNFalpha; APC1; Cachectin; DIF; Differentiation inducing factor; Macrophage cytotoxic factor; MCF; Necrosin; TNF a; TNF-alpha; TNF; TNF Macrophage Derived; TNF Monocyte Derived; TNF Superfamily Member 2; TNFA; TNFSF2; Tumor necrosis factor ligand superfamily member 2; Tumor Necrosis Factor Precurso; Tumour Necrosis Factor alpha; TNFA_HUMAN.
    产品应用Flow-Cyt=1ug/Test, ICC/IF=1:50-200

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原Recombinant human TNF alpha protein
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Growth factors > TNF

    Cardiovascular > Atherosclerosis > Vascular Inflammation > Inflammatory mediators

    Immunology > Innate Immunity > Cytokines > TNF Superfamily

    Metabolism > Types of disease > Metabolic disorders

    Microbiology > Organism > Virus > RNA Virus > ssRNA positive strand virus > SARS Coronavirus

    Signal Transduction > Growth Factors/Hormones > TNF

    亚基Homotrimer. Interacts with SPPL2B.
    亚细胞定位Cell membrane; Single-pass type II membrane protein._x000D_
    Tumor necrosis factor, membrane form: Membrane; Single-pass type II membrane protein._x000D_
    Tumor necrosis factor, soluble form: Secreted._x000D_
    C-domain 1: Secreted._x000D_
    C-domain 2: Secreted.
    翻译后修饰The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space._x000D_
    The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1._x000D_
    O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
    相似性Belongs to the tumor necrosis factor family.
    功能Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation._x000D_
    The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. Mutations in this gene affect susceptibility to cerebral malaria, septic shock, and Alzheimer disease. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Aug 2020]

     

    应用推荐稀释比例
    {Flow-Cyt}{1ug/Test}
    {ICC/IF}{1:50-200}

     

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