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- Bioss
- bs-7173R-Bio
- 2025年09月30日
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100ul
| 产品编号 | bs-7173R-Bio |
| 英文名称 | ZNF186 Rabbit pAb, Biotin conjugated |
| 中文名称 | Biotin标记的锌指蛋白186抗体 |
| 英文别名 | Cos 12; hZNF2; ZNF73; Zinc finger protein 186; Zinc finger protein 73; ZNF 186; ZNF 73; ZNF73_HUMAN. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human ZNF186 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚基 | Homodimer. Interacts with UBE2A and UBE2B, one homodimer binding one molecule of UBE2B. Interacts with HLTF and SHPRH. Interacts with SPRTN; leading to enhance chromatin association of RAD18 and RAD18-mediated PCNA ubiquitination and translesion DNA synthesis. |
| 亚细胞定位 | Nuclear. |
| 相似性 | Belongs to the RAD18 family. _x000D_ Contains 1 RING-type zinc finger. _x000D_ Contains 1 SAP domain. _x000D_ Contains 1 UBZ-type zinc finger. |
| 功能 | E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | ZNF73 may be involved in transcriptional regulation. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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ZNF186 Rabbit pAb, Biotin conjugated(bs-7173R-Bio)-100ul
￥2980
