- ￥2980
- Bioss
- bs-8611R-AP
- 2025年09月30日
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￥2980
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100ul
| 产品编号 | bs-8611R-AP |
| 英文名称 | USP22 Rabbit pAb, AP conjugated |
| 中文名称 | AP标记的去泛素化酶22抗体 |
| 英文别名 | Deubiquitinating enzyme 22; Ubiquitin carboxyl-terminal hydrolase 22; Ubiquitin thioesterase 22; Ubiquitin thiolesterase 22; Ubiquitin thiolesterase 8; Ubiquitin thiolesterase 8; Ubiquitin-specific processing protease 8; Ubiquitin-specific processing protease 8; Ubiquitin-specific-processing protease 22; UBP22_HUMAN; Usp22; USP3L. |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human USP22 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Deubiquitination Cell Biology > Proteolysis / Ubiquitin > Proteasome / Ubiquitin > Ub-like Proteins Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Ubiquitylation |
| 亚基 | Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ATXN7L3, ENY2 and USP22 form a subcomplex required for histone deubiquitination. Interacts directly with ATXN7L3; leading to its recritment to the SAGA complex. |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Moderately expressed in various tissues including heart and skeletal muscle, and weakly expressed in lung and liver. |
| 相似性 | Belongs to the peptidase C19 family. UBP8 subfamily. _x000D_ Contains 1 UBP-type zinc finger. |
| 功能 | Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. USP22 (ubiquitin specific peptidase 22), also known as USP3L, is a 525 amino acid protein that contains one UBP-type zinc finger and functions to catalyze the conversion of a ubiquitin C-terminal thioester to free ubiquitin and thiol, a reaction that may influence several cellular processes. Via its catalytic activity, USP22 is thought to play an important role in cell cycle progression and may also serve as a cancer stem cell marker. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
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USP22 Rabbit pAb, AP conjugated(bs-8611R-AP)-100ul
￥2980
