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- Bioss
- bs-21907R-AP
- 2025年09月30日
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100ul
| 产品编号 | bs-21907R-AP |
| 英文名称 | DLL1 Rabbit pAb, AP conjugated |
| 中文名称 | AP标记的Notch信号通路Delta样配体1抗体 |
| 英文别名 | delta(Drosophila) like 1; delta; delta like 1(Drosophila); delta like 1; delta like 1 protein; delta like protein 1; delta like protein 1 precursor; delta, Drosophila, homolog of 1; delta-like protein 1; delta1; DL1; DLL 1; Dll1; DLL1_HUMAN; Drosophila delta homolog 1; H-delta-1; OTTHUMP00000017690. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human DLL1 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Developmental Biology > Embryogenesis > Embryonic stem cells > Intracellular Developmental Biology > Embryogenesis > Somatogenesis Epigenetics and Nuclear Signaling > Transcription > Other factors Neuroscience > Neurology process > Neurogenesis Stem Cells > Embryonic Stem Cells > Surface Molecules Stem Cells > Hematopoietic Progenitors > Hematopoietic Stem Cells > Human Lineage Negative Stem Cells > Hematopoietic Progenitors > Surface Molecules Stem Cells > Signaling Pathways > Notch > Surface Molecules |
| 亚基 | Interacts with Notch receptors. |
| 亚细胞定位 | Membrane. |
| 组织特异性 | Expressed in heart and pancreas, with lower expression in brain and muscle and almost no expression in placenta, lung, liver and kidney. |
| 翻译后修饰 | Ubiquitinated by MIB (MIB1 or MIB2), leading to its endocytosis and subsequent degradation. |
| 相似性 | Contains 1 DSL domain. _x000D_ Contains 8 EGF-like domains. |
| 功能 | Acts as a ligand for Notch receptors. Blocks the differentiation of progenitor cells into the B-cell lineage while promoting the emergence of a population of cells with the characteristics of a T-cell/NK-cell precursor. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. Notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for Notch include Jagged, Jagged-2 and Delta. While blocking the differentiation of progenitor cells into the B cell lineage, Delta promotes the emergence of a population of cells with T cell/NK-cell characteristics. Delta is a membrane protein expressed in heart, pancreas, brain and muscle during gastrulation and early organogenesis, and in adult heart and lung. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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