EPHB4 Rabbit pAb, Biotin conjugated(bs-20467R-Bio)-100ul

EPHB4 Rabbit pAb, Biotin conju

gated(bs-20467R-Bio)-100ul
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  • ￥2980
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  • bs-20467R-Bio
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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    产品编号bs-20467R-Bio
    英文名称EPHB4 Rabbit pAb, Biotin conjugated
    中文名称Biotin标记的酪氨酸蛋白激酶受体B4抗体
    英文别名Eph receptor B4; EPHB4_HUMAN; Ephrin type-B receptor 4; Hepatoma Transmembrane Kinase; HTK; MYK1; TYRO11; Tyrosine-protein kinase receptor HTK; Tyrosine-protein kinase TYRO11.
    产品应用WB=1:500-2000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human EPHB4
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cardiovascular > Angiogenesis > Ephrins > Eph Receptors

    Neuroscience > Cell Type Marker > Neuron marker > Growth Cone

    Neuroscience > Neurology process > Growth and Development > Axonal Guidance Proteins

    Neuroscience > Neurotransmission > Intracellular Signaling > Kinases

    Neuroscience > Neurotransmission > Receptors / Channels > Tyrosine Kinase Receptors

    Stem Cells > Hematopoietic Progenitors > Surface Molecules

    亚基Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses.
    亚细胞定位Cell membrane; Single-pass type I membrane protein.
    组织特异性Abundantly expressed in placenta and in a range of primary tissues and malignant cell lines. Expressed in fetal, but not adult, brain, and in primitive and myeloid, but not lymphoid, hematopoietic cells._x000D_
    翻译后修饰Phosphorylated; autophosphorylation is stimulated by EFNB2.
    相似性Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily._x000D_
    Contains 2 fibronectin type-III domains._x000D_
    Contains 1 protein kinase domain._x000D_
    Contains 1 SAM (sterile alpha motif) domain.
    功能Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neiG‌‌HBoring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene binds to ephrin-B2 and plays an essential role in vascular development. [provided by RefSeq, Jul 2008]

     

    应用推荐稀释比例
    {WB}{1:500-2000}

     

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