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- bs-13159R-AP
- 2025年09月30日
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100ul
| 产品编号 | bs-13159R-AP |
| 英文名称 | phospho-FHOD1 (Thr1141) Rabbit pAb, AP conjugated |
| 中文名称 | AP标记的磷酸化肢体畸形相关蛋白FHOD1抗体 |
| 英文别名 | FHOD1(phospho T1141); p-FHOD1(phospho T1141); FH1/FH2 domain containing protein; FH1/FH2 domain-containing protein 1; Fhod1; FHOD1_HUMAN; FHOS; FHOS1; Formin homolog overexpressed in spleen 1; Formin homology 2 domain containing 1; Formin homology 2 domain containing protein 1; Formin homology 2 domain-containing protein 1. |
| 产品应用 | WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthesised phosphopeptide derived from human FHOD1 around the phosphorylation site of Thr1141 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Signal Transduction > Cytoskeleton / ECM > Cytoskeleton > Microfilaments > Actin etc > Actin Binding Proteins |
| 亚基 | Self-associates via the FH2 domain. Binds to F-actin via its N-terminus. Binds to the cytoplasmic domain of CD21 via its C-terminus. Interacts with ROCK1 in a Src-dependent manner. |
| 亚细胞定位 | Cytoplasm. Cytoplasm > cytoskeleton. Predominantly cytoplasmic. |
| 组织特异性 | Ubiquitous. Highly expressed in spleen. |
| 翻译后修饰 | Phosphorylated by ROCK1. |
| 相似性 | Belongs to the formin homology family. _x000D_ Contains 1 FH1 (formin homology 1) domain. _x000D_ Contains 1 FH2 (formin homology 2) domain. _x000D_ Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain. |
| 功能 | Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | The limb deformity (ld) locus influences normal limb development and gives rise to alternative mRNAs that can translate into a family of protein products known as formins. Formins play a crucial role in cytoskeletal reorganization by influencing actin filament assembly. The temporal genetic hierarchy influencing normal limb development can deregulate and mediate mammalian developmental syndromes. FHOD1 induces the formation of and associates with bundled actin stress fibers in response to the activity of the Rho-ROCK cascade. It influences several cellular activities including cell migration, cytoskeletal arrangement, signal transduction and gene expression. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
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phospho-FHOD1 (Thr1141) Rabbit pAb, AP conjugated(bs-13159R-AP)-100ul
￥2980
