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- Bioss
- bs-6702R-Bio
- 2025年09月30日
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100ul
| 产品编号 | bs-6702R-Bio |
| 英文名称 | TRPC3 Rabbit pAb, Biotin conjugated |
| 中文名称 | Biotin标记的色氨酸相关蛋白3抗体 |
| 英文别名 | Htrp 3; Htrp3; MGC124333; Mtrp3; Receptor activated cation channel TRP3v Short transient receptor potential channel 3; Transient receptor potential cation channel subfamily C member 3; Transient receptor potential channel 3; TRANSIENT RECEPTOR POTENTIAL DROSOPHILA HOMOLOG OF 3; Trp related protein 3; TRP3; TrpC3; Trrp3. |
| 产品应用 | IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human TRPC3 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cardiovascular > Heart > Hypertrophy Cardiovascular > Vasculature > Vasoconstriction Neuroscience > Neurology process > Neurogenesis Signal Transduction > Signaling Pathway > Calcium Signaling > Calcium Channels |
| 亚基 | Interacts with TRPC1, ITPR1, ITPR3, MX1 and RNF24. Interacts with JPH2; the interaction is involved in maintaining Ca(2+) homeostasis in skeletal muscle and is mediated by JPH2 'Ser-165' phosphorylation. |
| 亚细胞定位 | Cell Membrane; multi-pass membrane protein |
| 组织特异性 | Expressed predominantly in brain and at much lower levels in ovary, colon, small intestine, lung, prostate, placenta and testis. |
| 相似性 | Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC3 sub-subfamily. Contains 4 ANK repeats. |
| 功能 | Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol-1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | TRPC channels form the subfamily of channels in human most closely related to drosophila TRP channels. Structurally, this family shares a number of similar characteristics. At the proximal C-terminus of this sub-family is a TRP box motif containing the invariant EWKFAR sequence and between 3 and 4 ankyrin repeats near the N-terminus. These channels are non-selectively permeable to cations, with a selectivity of calcium over sodium variable among the different members. Many of TRPC channel subunits are able to coassemble. |
| 应用 | 推荐稀释比例 |
| {IHC-P} | {1:100-500} |
| {IHC-F} | {1:100-500} |
| {IF} | {1:100-500} |
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TRPC3 Rabbit pAb, Biotin conjugated(bs-6702R-Bio)-100ul
￥2980
