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- bs-6697R-PerCP-Cy7
- 2025年09月30日
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100ul
| 产品编号 | bs-6697R-PerCP-Cy7 |
| 英文名称 | DICER1 Rabbit pAb, PerCP-Cy7 conjugated |
| 中文名称 | PerCP-Cy7标记的核糖核酸酶Dicer抗体 |
| 英文别名 | DCR1c; Dcr1 homolog(Drosophila)DCR1; Dcr1 homolog(Drosophila); Dicer 1; Dicer 1 ribonuclease type III; Dicer; DICER_HUMANv Dicer1v Endoribonuclease Dicer; Helicase moiv; Helicase with RNAse motif; HERNA. |
| 产品应用 | ICC/IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human DICER1/Dicer |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA and 0.02% Proclin300. |
| 亚基 | Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Note that the trimeric RLC/miRLC is also referred to as RISC. Interacts with DHX9, EIF2C1, PIWIL1 and PRKRA. Associates with the 60S ribosome. |
| 亚细胞定位 | Cytoplasm. |
| 相似性 | Belongs to the helicase family. Dicer subfamily. _x000D_ Contains 1 Dicer dsRNA-binding fold domain. _x000D_ Contains 1 DRBM (double-stranded RNA-binding) domain. _x000D_ Contains 1 helicase ATP-binding domain. _x000D_ Contains 1 helicase C-terminal domain. _x000D_ Contains 1 PAZ domain. _x000D_ Contains 2 RNase III domains |
| 功能 | Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs. |
| 保存条件 | Store at 2-8°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010] |
| 应用 | 推荐稀释比例 |
| {ICC/IF} | {1:100-500} |
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DICER1 Rabbit pAb, PerCP-Cy7 conjugated(bs-6697R-PerCP-Cy7)-100ul
￥2980
