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- Bioss
- bs-16103R-AP
- 2025年09月30日
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100ul
| 产品编号 | bs-16103R-AP |
| 英文名称 | ZNF649 Rabbit pAb, AP conjugated |
| 中文名称 | AP标记的锌指蛋白649抗体 |
| 英文别名 | FLJ12644; Zinc finger protein 649; ZN649_HUMAN; ZNF649. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human ZNF649 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 亚细胞定位 | Nucleus. |
| 组织特异性 | Highly expressed in heart, skeletal muscle, and brain. Lower expression in liver, lung, kidney, pancreas and placenta. |
| 相似性 | Belongs to the krueppel C2H2-type zinc-finger protein family. _x000D_ Contains 10 C2H2-type zinc fingers. _x000D_ Contains 1 KRAB domain. |
| 功能 | Transcriptional repressor. Regulator of transcriptional factor complexes and may suppress SRE and AP-1 transcription activities mediated by growth factor signaling pathways. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. Zinc finger protein 649 (ZNF649) is a 505 amino acid member of the Krüppel C2H2-type zinc-finger protein family. Localized to the nucleus, ZNF649 is highly expressed in heart, brain and skeletal muscle with lower levels of expression in lung, liver, kidney and pancreas. ZNF649 contains ten C2H2-type zinc fingers and one KRAB domain through which it is thought to be involved in DNA-binding and transcriptional repression of mitogen-activated protein kinase signaling pathways. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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文献和实验SDS-PA gels, and subsequent detection of proteins using rabbit antisera and alkaline phosphatase-conjugated goat-anti-rabbit IgG, detected using bromo-chloro-indolyl phosphate (BCIP) and Nitro-blue tetrazolium (NBT) salts. ・
Developing Genetically Engineered Mouse Models to Study Tumor Suppression
Literature Cited Armstrong, J.F., Kaufman, M.H., Harrison, D.J., and Clarke, A.R. 1995. High‐frequency developmental abnormalities in p53‐deficient mice. Curr
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