ENPP6 Rabbit pAb, Biotin conjugated(bs-13076R-Bio)-100ul

ENPP6 Rabbit pAb, Biotin conju

gated(bs-13076R-Bio)-100ul
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  • ¥2980
  • Bioss已认证
  • bs-13076R-Bio
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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      100ul

    产品编号bs-13076R-Bio
    英文名称EN‌‌PP6 Rabbit pAb, Biotin conjugated
    中文名称Biotin标记的磷酸酶/磷酸二酯酶家族成员6抗体
    英文别名B830047L21Rik; E-N‌‌PP 6; Ectonucleotide pyrophosphatase/phosphodiesterase 6; ectonucleotide pyrophosphatase/phosphodiesterase family member 6; EN‌‌PP 6; N‌‌PP 6; N‌‌PP6; EN‌‌PP6_HUMAN.
    产品应用WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500, IF=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthetic peptide derived from human EN‌‌PP6
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Signal Transduction > Metabolism > Lipid metabolism

    亚基Homodimer; disulfide-linked.
    亚细胞定位Cell membrane; Single-pass type I membrane protein. Secreted. Note: A minor secreted form also exists.
    组织特异性Predominantly expressed in kidney and brain. In the kidney, expressed specifically in the proximal tubules and thin descending limbs of Henle (at protein level).
    相似性Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.
    功能EN‌‌PP6 is a choline-specific glycerophosphodiester phosphodiesterase, which hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5 prime-monophosphate. It hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. EN‌‌PP6 has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. EN‌‌PP6 also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently. EN‌‌PP6 is predominantly expressed in kidney and brain.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料N‌‌PP6 is a 440 amino acid member of the nucleotide pyrophosphatase/phosphodiesterase family. N‌‌PP6 is a secreted and single-pass type I membrane protein. Predominantly expressed in brain and kidney, N‌‌PP6 is a choline-specific glycerophosphodiester phosphodiesterase. N‌‌PP6 can hydrolyze the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine, glycerophosphorylcholine, sphingosylphosphorylcholine and lysophosphatidylcholine (LPC). N‌‌PP6 has been found to have a preference for LPC with polyunsaturated or short fatty acids. The gene encoding N‌‌PP6 maps to human chromosome 4, which consists of approximately 6% of the human genome and nearly 900 genes. Chromosome 4 is associated with Huntington's disease, FGFR-3, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}
    {IF}{1:100-500}

     

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