phospho-eNOS (Ser117) Rabbit pAb, AP conjugated(bs-13072R-AP)-100ul

phospho-eNOS (Ser117) Rabbit p

Ab, AP conjugated(bs-13072R-AP)-100ul
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  • ￥2980
  • Bioss已认证
  • bs-13072R-AP
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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      100ul

    产品编号bs-13072R-AP
    英文名称phospho-eNOS (Ser117) Rabbit pAb, AP conjugated
    中文名称AP标记的磷酸化一‌‌氧化氮合成酶3（内皮型）抗体
    英文别名eNOS(phospho S116); eNOS(phospho S117); p-eNOS(phospho S117); eNOS(phospho-Ser117); cNOS; eNOS; Constitutive NOS; EC NOS; ecNOS; Endothelial nitric oxidase synthase; Endothelial nitric oxide synthase; Endothelial nitric oxide synthase 3; Endothelial NOS; Nitric oxide synthase 3(endothelial cell); Nitric oxide synthase 3; Nitric oxide synthase 3 endothelial cell; Nitric oxide synthase endothelial; nitric oxide synthase, endothelial; NOS 3; NOS III; NOS type III; NOS3; NOSIII; NOS3_HUMAN.
    产品应用WB=1:500-2000, IHC-P=1:100-500, IHC-F=1:100-500

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated Synthesised phosphopeptide derived from mouse eNOS around the phosphorylation site of Ser117
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cancer > Cancer Metabolism > Response to hypoxia

    Cardiovascular > Blood > Platelets

    Cardiovascular > Vasculature > Vasodilation > Nitric oxide associated

    Cell Biology > Other Antibodies > Oxidative Stress

    Metabolism > Pathways and Processes > Metabolism processes > Hypoxia

    Metabolism > Pathways and Processes > Redox metabolism > Oxidative stress

    Neuroscience > Neurotransmission > Nitric Oxide > NOS

    亚基Homodimer. Interacts with NOSIP and NOSTRIN.
    亚细胞定位Cell membrane. Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity.
    组织特异性Platelets, placenta, liver and kidney.
    翻译后修饰Phosphorylation by AMPK at Ser-1177 in the presence of Ca(2+)-calmodulin (CaM) activates activity. In absence of Ca(2+)-calmodulin, AMPK also phosphorylates Thr-495, resulting in inhibition of activity. Phosphorylation of Ser-114 by CDK5 reduces activity.
    相似性Belongs to the NOS family.
    _x000D_ Contains 1 FAD-binding FR-type domain.
    _x000D_ Contains 1 flavodoxin-like domain.
    功能Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets._x000D_
    Isoform eNOS13C: Lacks eNOS activity, dominant-negative form that may down-regulate eNOS activity by forming heterodimers with isoform 1.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料Nitric oxide synthase NOS oxidizes a guanidine nitrogen of arginine releasing nitric oxide in the form of a free radical and citrulline. Nitric oxide thus generated acts as a messenger in diverse functions including vasodilation neurotransmission, anti tumor and anti pathogenic activities. NOS is classified under three types: neuronal NOS (nNOS) or brain NOS (bNOS); inducible NOS (iNOS) or macrophage NOS (mNOS); and endothelial NOS (eNOS).

     

    应用推荐稀释比例
    {WB}{1:500-2000}
    {IHC-P}{1:100-500}
    {IHC-F}{1:100-500}

     

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