phospho-EEF2 (Thr56 + Thr58) Rabbit pAb, AP conjugated(bs-13057R-AP)-100ul

phospho-EEF2 (Thr56 + Thr58) R

abbit pAb, AP conjugated(bs-13057R-AP)-100ul
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  • ￥2980
  • Bioss已认证
  • bs-13057R-AP
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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北京博奥森生物技术有限公司
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    • 规格：

      100ul

    产品编号bs-13057R-AP
    英文名称phospho-EEF2 (Thr56 + Thr58) Rabbit pAb, AP conjugated
    中文名称AP标记的磷酸化真核翻译延长因子2抗体
    英文别名EEF2(phospho T56+T58); p-EEF2(phospho T56+T58); EEF 2; Eef2; EF-2; EF2; EF2_HUMAN; Elongation factor 2; Eukaryotic translation elongation factor 2; Polypeptidyl tRNA translocase.
    产品应用WB=1:500-2000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated Synthesised phosphopeptide derived from human EEF2 around the phosphorylation site of Thr56+Thr58
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Epigenetics and Nuclear Signaling > DNA / RNA > Translation > Regulation

    亚基Component of the mRNA surveillance SURF complex, at least composed of ERF1, ERF3 (ERF3A or ERF3B), EEF2, UPF1/RENT1, SMG1, SMG8 and SMG9.
    亚细胞定位Cytoplasm.
    翻译后修饰Phosphorylation by EF-2 kinase completely inactivates EF-2._x000D_
    Diphthamide is 2-[3-carboxyamido-3-(trimethyl-ammonio)propyl]histidine. Diphthamide can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A, thus arresting protein synthesis._x000D_
    ISGylated.
    相似性Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.
    功能Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料EEF2 is a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation.

     

    应用推荐稀释比例
    {WB}{1:500-2000}

     

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