phospho-EPO Receptor (Tyr485) Rabbit pAb, HRP conjugated(bs-13088R-HRP)-100ul

phospho-EPO Receptor (Tyr485)

Rabbit pAb, HRP conjugated(bs-13088R-HRP)-100ul
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  • ￥2980
  • Bioss已认证
  • bs-13088R-HRP
  • 2025年09月30日
  • 产品信息以Bioss网站为准
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    • 规格：

      100ul

    产品编号bs-13088R-HRP
    英文名称phospho-EPO Receptor (Tyr485) Rabbit pAb, HRP conjugated
    中文名称HRP标记的磷酸化红细胞生成素受体抗体
    英文别名EPO Receptor(phospho Y485); p-EPO Receptor(phospho Y485); EPOR(phospho Y485); p-EPOR(phospho Y485); erythropoietin receptor; EPO R; EPO Receptor; Erythropoietin receptor precursor; EPOR_HUMAN; MGC138358.
    产品应用WB=1:500-2000

    Not yet tested in other applications.
    Optimal working dilutions must be determined by the end user.

    抗体来源Rabbit
    免疫原KLH conjugated synthesised phosphopeptide derived from human EPO Receptor around the phosphorylation site of Tyr485
    亚型IgG
    纯化方法affinity purified by Protein A
    克隆类型Polyclonal
    浓度1mg/ml
    储存液0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
    研究领域

    Cardiovascular > Angiogenesis > Angiogenic Factors

    Cardiovascular > Angiogenesis > Endothelial Cell Markers

    Cardiovascular > Atherosclerosis > Ischemia / Reperfusion

    Cardiovascular > Heart > Apoptosis

    Cardiovascular > Heart > Hypertrophy

    Immunology > Immunoglobulins > Receptors

    Signal Transduction > Signaling Pathway > G Protein Signaling > Small G Proteins

    Stem Cells > Hematopoietic Progenitors > Surface Molecules

    亚基Forms homodimers on EPO stimulation. The tyrosine-phosphorylated form interacts with several SH2 domain-containing proteins including LYN, the adapter protein APS, PTPN6, PTPN11, JAK2, PI3 kinases, STAT5A/B, SOCS3, CRKL. Interacts with IN‌‌PP5D/SHIP1. The N-terminal SH2 domain of PTPN6 binds Tyr-454 and inhibits signaling through dephosphorylation of JAK2. APS binding also inhibits the JAK-STAT signaling. Binding to PTPN11, preferentially through the N-terminal SH2 domain, promotes mitogenesis and phosphorylation of PTPN11. Binding of JAK2 (through its N-terminal) promotes cell-surface expression. Interaction with the ubiquitin ligase NOSIP mediates EPO-induced cell proliferation. Interacts with ATXN2L.
    亚细胞定位Cell membrane; Single-pass type I membrane protein._x000D_
    Isoform EPOR-S: Secreted. Note=Secreted and located to the cell surface.
    组织特异性Erythroid cells and erythroid progenitor cells. Isoform EPOR-F is the most abundant form in EPO-dependent erythroleukemia cells and in late-stage erythroid progenitors. Isoform EPOR-S and isoform EPOR-T are the predominant forms in bone marrow. Isoform EPOR-T is the most abundant from in early-stage erythroid progenitor cells.
    翻译后修饰On EPO stimulation, phosphorylated on C-terminal tyrosine residues by JAK2. The phosphotyrosine motifs are also recruitment sites for several SH2-containing proteins and adapter proteins which mediate cell proliferation. Phosphorylation on Tyr-454 is required for PTPN6 interaction, Tyr-426 for PTPN11. Tyr-426 is also required for SOCS3 binding, but Tyr-454/Tyr-456 motif is the preferred binding site.
    _x000D_ Ubiquitinated by NOSIP; appears to be either multi-monoubiquitinated or polyubiquitinated. Ubiquitination mediates proliferation and survival of EPO-dependent cells.
    相似性Belongs to the type I cytokine receptor family. Type 1 subfamily. Contains 1 fibronectin type-III domain.
    功能Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase._x000D_ Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling.
    保存条件Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
    背景资料The erythropoietin receptor (EPOR) is a member of the cytokine receptor family. There are several isoforms including: EPOR-F (full length), EPOR-S (soluble form), and EPOR-T (truncated form). Upon erythropoietin (EPO) binding, the EPOR activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated EPOR appears to have a role in erythroid cell survival. Defects in the EPOR may produce erythroleukemia and familial erythrocytosis. A functional EPOR is found in the cardiovascular system, including endothelial cells and cardiomyocytes, and data suggest that the EPO/EPO receptor system plays an important role in cardiac function. In animal studies, treatment with EPO during ischemia/reperfusion in the heart has been shown to limit the infarct size and the extent of apoptosis.

     

    应用推荐稀释比例
    {WB}{1:500-2000}

     

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