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- bsm-52850R-FITC
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100ul
| 产品编号 | bsm-52850R-FITC |
| 英文名称 | KLF4 Rabbit mAb, FITC conjugated |
| 中文名称 | FITC标记的KLF4重组兔单克隆抗体 |
| 英文别名 | Endothelial Kruppel like zinc finger protein; EZF; GKLF; KLF; Kruppel like factor 4(Epithelial zinc finger protein EZF)(Gut enriched Krueppel like factor); Kruppel like factor 4(gut); Krueppel-like factor 4; EZF; GKLF; KLF 4; KLF-4; Krueppel like factor 4; KLF4_HUMAN. |
| 中文别名 | 肠道内富含的Kruppel样因子/上皮锌指蛋白4抗体 |
| 产品应用 | Flow-Cyt=1ug/Test, IF=1:50-200, ICC/IF=1:100-500 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | Recombinant protein within human KLF4 aa 1-500 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Monoclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Oncoproteins/suppressors > Oncoproteins > Transcription factors Cancer > Oncoproteins/suppressors > Tumor suppressors Cardiovascular > Angiogenesis > Endothelial Cell Markers Cardiovascular > Heart > Hypertrophy > Transcription factors Developmental Biology > Embryogenesis > Embryonic stem cells > Surface molecules Epigenetics and Nuclear Signaling > Cell cycle > Cell Cycle Inhibitors Epigenetics and Nuclear Signaling > Cell cycle > Cell Differentiation Epigenetics and Nuclear Signaling > Transcription > Domain Families > Krueppel like factor Epigenetics and Nuclear Signaling > Transcription > Krueppel like factor Epigenetics and Nuclear Signaling > Transcription > Other factors Epigenetics and Nuclear Signaling > Transcription > Transcription Factors Stem Cells > Embryonic Stem Cells > Intracellular |
| 亚基 | Interacts with POU5F1/OCT4 and SOX2. Interacts with MUC1 (via the C-terminal domain). |
| 亚细胞定位 | Nucleus. |
| 翻译后修饰 | Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein. |
| 相似性 | Belongs to the krueppel C2H2-type zinc-finger protein family. |
| 功能 | Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | KLF4 is a transcription factor that works with Sp1 to activate the Laminin gamma1 chain gene. It binds the CACCC core sequence. KLF4 may be involved in the differentiation of epithelial cells and may also function in the development of the skeleton and kidney. KLF4 also has roles as both an oncogene and a tumor suppressor. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {1ug/Test} |
| {IF} | {1:50-200} |
| {ICC/IF} | {1:100-500} |
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