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- Bioss
- bs-2016R-PerCP
- 2025年09月30日
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100ul
| 产品编号 | bs-2016R-PerCP |
| 英文名称 | Integrin Alpha V + Beta 1 Rabbit pAb, PerCP conjugated |
| 中文名称 | PerCP标记的整合素αVβ1抗体 |
| 英文别名 | Integrin alpha 5 beta 1; fibronectin receptor alpha; ITGAV; CD51; DKFZp686A08142; MSK8; Msk 8; VNR; similar to Integrin alpha-V precursor; Vitronectin receptor subunit alpha; CD51 antigen; HGNC; Vitronectin receptor alpha polypeptide; Vitronectin receptor alpha polypeptide antigen CD51; VNRA; Integrin alpha 5 beta 1; VLA-5; Integrin alpha-5; ITGA5; ITA5_HUMAN; Integrin beta-1; ITGB1; ITB1_HUMAN; |
| 产品应用 | Flow-Cyt=1μg /test Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic Mixed peptides 915-948/1048(human Integrin αV)+ 21-70/798(human Integrin β1) |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA and 0.02% Proclin300. |
| 研究领域 | Cardiovascular > Angiogenesis > Adhesion / ECM > Integrins Cardiovascular > Atherosclerosis > Vascular Inflammation > Leukocyte recruitment > Integrins Cardiovascular > Blood > Platelets Microbiology > Interspecies Interaction > Host Virus Interaction Stem Cells > Hematopoietic Progenitors > Lymphoid > T Lymphocytic Lineage |
| 亚基 | Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-V associates with either beta-1, beta-3, beta-5, beta-6 or beta-8 subunit. Interacts with HIV-1 Tat. Alpha-V/beta-6 binds to foot-and-mouth disease virus (FMDV) VP1 protein and acts as a receptor for this viru. Alpha-V/beta-6 binds to coxsackievirus A9 and coxsackievirus B1 capsid proteins and acts as a receptor for these viruses. Interacts with RAB25. |
| 亚细胞定位 | Cell Membrane |
| 相似性 | Belongs to the integrin alpha chain family._x000D_
Contains 7 FG-GAP repeats. |
| 功能 | The alpha-V integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF. They recognize the sequence R-G-D in a wide array of ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions. |
| 保存条件 | Store at 2-8°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metatastatic diffusion of tumour cells. ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; ITGB1, ITGB3, ITGB5, ITGB6, and ITGB8), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. |
| 应用 | 推荐稀释比例 |
| {Flow-Cyt} | {1μg /test} |
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Integrin Alpha V + Beta 1 Rabbit pAb, PerCP conjugated(bs-2016R-PerCP)-100ul
￥2980
