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- Bioss
- bs-11020R-HRP
- 2025年09月30日
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100ul
| 产品编号 | bs-11020R-HRP |
| 英文名称 | AFAP1L2 Rabbit pAb, HRP conjugated |
| 中文名称 | HRP标记的AFAP1L2抗体 |
| 英文别名 | KIAA1914; XB130; Actin filament-associated protein 1-like 2; AF1L2_HUMAN; AFAP1-like protein 2; afap1l2. |
| 产品应用 | WB=1:500-2000 Not yet tested in other applications. |
| 抗体来源 | Rabbit |
| 免疫原 | KLH conjugated synthetic peptide derived from human AFAP1L2 |
| 亚型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 克隆类型 | Polyclonal |
| 浓度 | 1mg/ml |
| 储存液 | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| 研究领域 | Cancer > Signal transduction > Protein phosphorylation > Tyrosine kinases > Src family Epigenetics and Nuclear Signaling > Transcription > Other factors Signal Transduction > Adapters > Cytoplasmic Signal Transduction > Protein Phosphorylation > Tyrosine Kinases > Src Family |
| 亚基 | Interacts with SRC. Interacts with LCK when tyrosine phosphorylated. |
| 亚细胞定位 | Cytoplasm. |
| 组织特异性 | Detected in spleen and thyroid, and at lower levels in kidney, brain, lung and pancreas. |
| 翻译后修饰 | Tyrosine phosphorylated (by SRC). |
| 相似性 | Contains 2 PH domains. |
| 功能 | May play a role in a signaling cascade by enhancing the kinase activity of SRC. Contributes to SRC-regulated transcription activation. |
| 保存条件 | Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles. |
| 注意事项 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 背景资料 | Actin filament associated protein (AFAP-110) interacts directly with actin filaments through its C-terminal actin-binding domain. AFAP-110 contains additional protein-binding domains as well, and serves as an adaptor protein. By linking signaling molecules to actin filaments, AFAP-110 provides a platform for the preparation of larger signaling complexes, activates Src kinases in response to cellular signals and also directly affects Actin organization as an Actin filament cross-linking protein. AFAP-1L2 (Actin filament-associated protein 1-like 2), also known as XB130, is a 818 amino acid cytoplasmic protein that contains two Pleckstrin homology (PH) domains, which are normally found in proteins involved in intracellular signaling. Like its relative AFAP110, AFAP-1L2 interacts with Src kinase and may play a role in Src-regulated transcription activation. AFAP-1L2 is expressed in thyroid and spleen and can also be detected at lower levels in lung, brain, pancreas and kidney. There are four isoforms of AFAP-1L2 that are produced as a result of alternative splicing events. |
| 应用 | 推荐稀释比例 |
| {WB} | {1:500-2000} |
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AFAP1L2 Rabbit pAb, HRP conjugated(bs-11020R-HRP)-100ul
￥2980
